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The molecular structures are mirror images of each other. Only one sulfonyl O atom takes part in intramolecular hydrogen bonding as a proton acceptor and this atom is different in the two enantiomorphic structures. As a result, the S atom becomes a pseudo-stereogenic centre. This fact is worth taking into account due to the different biological activities of the enantiomorphic forms. One form possesses a high analgesic activity, while the other form revealed a high anti-inflammatory activity.<\/jats:p>","DOI":"10.1107\/s2053229619016450","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T17:19:07Z","timestamp":1575998347000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":3,"title":["Biological properties of two enantiomorphic forms of<i>N<\/i>-(2,6-dimethylphenyl)-4-hydroxy-2,2-dioxo-1<i>H<\/i>-2\u03bb<sup>6<\/sup>,1-benzothiazine-3-carboxamide, a structural analogue of piroxicam"],"prefix":"10.1107","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-1061","authenticated-orcid":true,"given":"Svitlana V.","family":"Shishkina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7302-4922","authenticated-orcid":true,"given":"Igor V.","family":"Ukrainets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga V.","family":"Vashchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natali I.","family":"Voloshchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavlo S.","family":"Bondarenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidiya A.","family":"Petrushova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"ku3258_bb1","unstructured":"Agilent (2012). 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