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The complex was characterized by elemental analysis, Fourier transform IR spectroscopy, electrospray ionization mass spectrometry and single-crystal X-ray diffraction. Two chloride ligands and two bidentate <jats:italic>L<\/jats:italic> ligands coordinate the Cu<jats:sup>II<\/jats:sup> centre in <jats:bold>1<\/jats:bold> in a Jahn\u2013Teller-distorted octahedral geometry of rather unusual configuration: a chloride substituent and a pyrazole N atom of an <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032-chelating ligand occupy the more distant axial positions. Classical O\u2014H...O hydrogen bonds and O\u2014H...Cl interactions link neighbouring complex molecules and cocrystallized methanol molecules into chains that propagate parallel to the <jats:italic>b<\/jats:italic> direction. The title compound shows intriguing bioactivity: the effects of <jats:bold>1<\/jats:bold> on the enzymatic activity of protein tyrosine phosphatase 1B (PTP1B) and on the viability of human breast cancer cells of cell line MCF7 were evaluated. Complex <jats:bold>1<\/jats:bold>, with an IC<jats:sub>50<\/jats:sub> value of 0.51\u2005\u00b5<jats:italic>M<\/jats:italic>, can efficiently inhibit PTP1B activity. An enzyme kinetic assay suggests that <jats:bold>1<\/jats:bold> inhibits PTP1B in a noncompetitive manner. A fluorescence titration assay indicates that <jats:bold>1<\/jats:bold> has a strong affinity for PTP1B, with a binding constant of 4.39 \u00d7 10<jats:sup>6<\/jats:sup> \n                  <jats:italic>M<\/jats:italic>\n                  <jats:sup>\u22121<\/jats:sup>. Complex <jats:bold>1<\/jats:bold> may also effectively decrease the viability of MCF7 cells in an extent comparable to that of cisplatin (IC<jats:sub>50<\/jats:sub>\u00a0= 6.3\u2005\u00b5<jats:italic>M<\/jats:italic>). The new copper complex therefore represents a promising PTP1B inhibitor and an efficient antiproliferation reagent against MCF7 cells.<\/jats:p>","DOI":"10.1107\/s2053229621009748","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T14:26:08Z","timestamp":1632752768000},"page":"641-648","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, structure and <i>in vitro<\/i> biological properties of a new copper(II) complex with 4-{[3-(pyridin-2-yl)-1<i>H<\/i>-pyrazol-1-yl]methyl}benzoic acid"],"prefix":"10.1107","volume":"77","author":[{"given":"Xinhua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-0061","authenticated-orcid":true,"given":"Ulli","family":"Englert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-4032","authenticated-orcid":true,"given":"Lizhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ky3208_bb1","unstructured":"Bruker (2009). 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