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These compounds included two mono-methoxy-substituted derivatives: 2-methoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene {systematic name: 1-[(\n                    <jats:italic>E<\/jats:italic>\n                    )-2-(2-methoxyphenyl)ethenyl]-4-(methylsulfanyl)benzene} (\n                    <jats:bold>1<\/jats:bold>\n                    ) and 3-methoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>2<\/jats:bold>\n                    ), both C\n                    <jats:sub>16<\/jats:sub>\n                    H\n                    <jats:sub>16<\/jats:sub>\n                    OS; four dimethoxy derivatives: 2,3-dimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>3<\/jats:bold>\n                    ), 2,5-dimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>4<\/jats:bold>\n                    ), 3,5-dimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>5<\/jats:bold>\n                    ) and 2,4-dimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>6<\/jats:bold>\n                    ), all C\n                    <jats:sub>17<\/jats:sub>\n                    H\n                    <jats:sub>18<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    S; and three trimethoxy compounds: 2,4,5-trimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>7<\/jats:bold>\n                    ), 3,4,5-trimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>8<\/jats:bold>\n                    ) and 2,4,6-trimethoxy-4\u2032-methylthio-\n                    <jats:italic>trans<\/jats:italic>\n                    -stilbene (\n                    <jats:bold>9<\/jats:bold>\n                    ), all C\n                    <jats:sub>18<\/jats:sub>\n                    H\n                    <jats:sub>20<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    S. The geometries of the compounds in the crystal structures were compared with those found during docking studies at the active site of the receptor, and some relevant differences were identified. Intermolecular interactions were analyzed using three different methods. First, the (3,\u22121) critical points of the gradient field of the electron density were identified, and then the appropriate contacts were analyzed using their geometrical characteristics and interaction energy calculations. The results confirmed the importance of weak delocalized interactions in the construction of the crystal structures, and the results of different methods (PIXEL and DFT) were comparable in the absence of strong well-defined intermolecular interactions.\n                  <\/jats:p>","DOI":"10.1107\/s2053229622000420","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:31:02Z","timestamp":1643103062000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Weak intermolecular interactions in a series of biologically active 4\u2032-methylthio-\n                    <i>trans<\/i>\n                    -stilbenes"],"prefix":"10.1107","volume":"78","author":[{"given":"Anita M.","family":"Grze\u015bkiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Stefa\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-3322","authenticated-orcid":true,"given":"Zbigniew","family":"Dutkiewicz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-9169","authenticated-orcid":true,"given":"Maciej","family":"Kubicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"wp3023_bb1","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1021\/jp0367124","volume":"108","author":"Baciocchi","year":"2004","journal-title":"J. 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