{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:24:12Z","timestamp":1785435852878,"version":"3.56.0"},"reference-count":40,"publisher":"International Union of Crystallography (IUCr)","issue":"7","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"accepted":{"date-parts":[[2023,6,22]]},"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>\n                    Three new 2,6-disubstituted thiosemicarbazone derivatives of pyridine, namely, 2-{amino[6-(pyrrolidin-1-yl)pyridin-2-yl]methylidene}-\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -dimethylhydrazine-1-carbothioamide, C\n                    <jats:sub>13<\/jats:sub>\n                    H\n                    <jats:sub>20<\/jats:sub>\n                    N\n                    <jats:sub>6<\/jats:sub>\n                    S, 2-{amino[6-(piperidin-1-yl)pyridin-2-yl]methylidene}-\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -dimethylhydrazine-1-carbothioamide, C\n                    <jats:sub>14<\/jats:sub>\n                    H\n                    <jats:sub>22<\/jats:sub>\n                    N\n                    <jats:sub>6<\/jats:sub>\n                    S, and 2-[amino(6-phenoxypyridin-2-yl)methylidene]-\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -dimethylhydrazine-1-carbothioamide monohydrate, C\n                    <jats:sub>15<\/jats:sub>\n                    H\n                    <jats:sub>17<\/jats:sub>\n                    N\n                    <jats:sub>5<\/jats:sub>\n                    OS\u00b7H\n                    <jats:sub>2<\/jats:sub>\n                    O, have been synthesized and characterized by NMR spectroscopy and low-temperature single-crystal X-ray diffraction. In addition, their antibacterial and anti-yeast activities have been determined. The ability of the tested compounds to inhibit bacterial growth was comparable to vancomycin as a reference drug. Compared to isoniazid (MIC 0.125 and 8\u2005\u00b5g\u2005ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), the compounds showed the ability to inhibit the growth of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    to a moderate degree for the standard strain and at the same level or higher (MIC 4\u20138\u2005\u00b5g\u2005ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for the resistant strain. All three compounds adopt the zwitterionic form in the crystal structure regardless of the presence or absence of solvent molecules.\n                  <\/jats:p>","DOI":"10.1107\/s2053229623005521","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T11:45:26Z","timestamp":1687607126000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis, structure, ADME and biological activity of three 2,6-disubstituted thiosemicarbazone derivatives"],"prefix":"10.1107","volume":"79","author":[{"given":"Dagmara","family":"Ziembicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-1767","authenticated-orcid":true,"given":"Andrzej","family":"Olczak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00s8fpf52","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Gobis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-0387","authenticated-orcid":true,"given":"Izabela","family":"Korona-G\u0142owniak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016f61126","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pietrzak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00s8fpf52","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Augustynowicz-Kope\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-4934","authenticated-orcid":true,"given":"Agnieszka","family":"G\u0142ogowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zaborowski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00s8fpf52","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Szczesio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00s8fpf52","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"vp3029_bb1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jiph.2020.12.033","volume":"14","author":"Al-Khattaf","year":"2021","journal-title":"J. Infect. Publ. Heal."},{"key":"vp3029_bb2","doi-asserted-by":"crossref","first-page":"503640","DOI":"10.1016\/j.mrgentox.2023.503640","volume":"888","author":"Baluku","year":"2023","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"vp3029_bb3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/zaac.200400345","volume":"631","author":"Bermejo","year":"2005","journal-title":"Z. Anorg. Allg. Chem."},{"key":"vp3029_bb4","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/anie.199515551","volume":"34","author":"Bernstein","year":"1995","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"vp3029_bb5","doi-asserted-by":"crossref","first-page":"12763","DOI":"10.1021\/jp907658w","volume":"113","author":"Biswal","year":"2009","journal-title":"J. Phys. Chem. A"},{"key":"vp3029_bb6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1515\/znb-2000-0612","volume":"55","author":"Casti\u00f1eiras","year":"2000","journal-title":"Z. Naturforsch. B Chem. Sci."},{"key":"vp3029_bb7","unstructured":"Centers for Disease Control and Prevention. (2019). Antibiotic Resistance Threats in the United States. https:\/\/www.cdc.gov\/drugresistance\/pdf\/threats-report\/2019-ar-threats-report-508.pdf."},{"key":"vp3029_bb8","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"vp3029_bb9","first-page":"291","volume":"5","author":"Dheda","year":"2017","journal-title":"Respir. Med."},{"key":"vp3029_bb10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"key":"vp3029_bb11","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm000292e","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"vp3029_bb12","doi-asserted-by":"crossref","first-page":"112362","DOI":"10.1016\/j.biopha.2021.112362","volume":"144","author":"Faria","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"vp3029_bb13","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1021\/acs.cgd.6b01620","volume":"17","author":"Francuski","year":"2017","journal-title":"Cryst. Growth Des."},{"key":"vp3029_bb14","doi-asserted-by":"crossref","first-page":"135325","DOI":"10.1016\/j.molstruc.2023.135325","volume":"1283","author":"Gavadia","year":"2023","journal-title":"J. Mol. Struct."},{"key":"vp3029_bb15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"key":"vp3029_bb16","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.3390\/ma15165513","volume":"15","author":"Gobis","year":"2022","journal-title":"Materials"},{"key":"vp3029_bb17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1107\/S2052520616003954","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Cryst. B"},{"key":"vp3029_bb18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejmech.2017.04.002","volume":"133","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"vp3029_bb19","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1107\/S0021889811043202","volume":"44","author":"H\u00fcbschle","year":"2011","journal-title":"J. Appl. Cryst."},{"key":"vp3029_bb20","doi-asserted-by":"crossref","first-page":"112106","DOI":"10.1016\/j.ejmech.2020.112106","volume":"190","author":"Krause","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"vp3029_bb21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"vp3029_bb22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1107\/S205225251700848X","volume":"4","author":"Mackenzie","year":"2017","journal-title":"IUCrJ"},{"key":"vp3029_bb23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1107\/S1600576719014092","volume":"53","author":"Macrae","year":"2020","journal-title":"J. Appl. Cryst."},{"key":"vp3029_bb24","doi-asserted-by":"crossref","first-page":"123080","DOI":"10.1016\/j.jchromb.2021.123080","volume":"1188","author":"Martins Gouv\u00eaa","year":"2022","journal-title":"J. Chromatogr. B"},{"key":"vp3029_bb25","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jm015507e","volume":"44","author":"Muegge","year":"2001","journal-title":"J. Med. Chem."},{"key":"vp3029_bb26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijantimicag.2009.06.031","volume":"35","author":"O'Donnell","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"vp3029_bb27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1107\/S2052519213010014","volume":"69","author":"Parsons","year":"2013","journal-title":"Acta Cryst. B"},{"key":"vp3029_bb28","unstructured":"President's Council of Advisors on Science and Technology (2014). Report to the President on combating antibiotic resistance. https:\/\/obamawhitehouse.archives.gov\/sites\/default\/files\/microsites\/ostp\/PCAST\/pcast_carb_report_sept2014.pdf. Published September 2014."},{"key":"vp3029_bb29","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1016\/j.bmc.2019.07.045","volume":"27","author":"Reis","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"vp3029_bb30","unstructured":"Rigaku OD (2022). CrysAlis PRO. Rigaku Oxford Diffraction Ltd, Yarnton, Oxfordshire, England."},{"key":"vp3029_bb31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. A"},{"key":"vp3029_bb32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. C"},{"key":"vp3029_bb33","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1107\/S1600576721002910","volume":"54","author":"Spackman","year":"2021","journal-title":"J. Appl. Cryst."},{"key":"vp3029_bb34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1107\/S2053229620007822","volume":"76","author":"Szczesio","year":"2020","journal-title":"Acta Cryst. C"},{"key":"vp3029_bb35","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"vp3029_bb36","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1107\/S0021889810022120","volume":"43","author":"Westrip","year":"2010","journal-title":"J. Appl. Cryst."},{"key":"vp3029_bb37","unstructured":"World Health Organization (2015). The end TB strategy. World Health Organization, Geneva, Switzerland. (Accessed on 20 March 2023.) https:\/\/apps.who.int\/iris\/handle\/10665\/331326."},{"key":"vp3029_bb38","unstructured":"World Health Organization (2022). Global Tuberculosis Report 2022. World Health Organization, Geneva, Switzerland. (Accessed on 20 March 2023.) https:\/\/www.who.int\/publications\/i\/item\/9789240061729."},{"key":"vp3029_bb39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.molstruc.2017.04.067","volume":"1142","author":"\u017bes\u0142awska","year":"2017","journal-title":"J. Mol. Struct."},{"key":"vp3029_bb40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3390\/ma16010448","volume":"16","author":"Ziembicka","year":"2023","journal-title":"Materials"}],"container-title":["Acta Crystallographica Section C Structural Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/journals.iucr.org\/c\/issues\/2023\/07\/00\/vp3029\/vp3029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.iucr.org\/c\/issues\/2023\/07\/00\/vp3029\/vp3029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:25:24Z","timestamp":1736749524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.iucr.org\/paper?S2053229623005521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["S2053229623005521"],"URL":"https:\/\/doi.org\/10.1107\/s2053229623005521","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp3029sup1.cif","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30294sup2.hkl","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30295sup3.hkl","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30296sup4.hkl","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30294sup5.cml","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30295sup6.cml","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S2053229623005521\/vp30296sup7.cml","asserted-by":"subject"}]},"ISSN":["2053-2296"],"issn-type":[{"value":"2053-2296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"Acta Crystallographica Section C: Structural Chemistry","order":0,"name":"journal","label":"Publication","explanation":{"URL":"https:\/\/journals.iucr.org\/c"},"group":{"name":"general","label":"General"}},{"value":"research papers","order":1,"name":"content_type","label":"Content type","explanation":{"URL":"https:\/\/journals.iucr.org\/c\/services\/notesforauthors.html"},"group":{"name":"general","label":"General"}},{"value":"Available","URL":"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?vp3029","order":2,"name":"article_metrics","label":"Article metrics","group":{"name":"general","label":"General"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"19 April 2023","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication history"}},{"value":"22 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication history"}},{"value":"27 June 2023","order":2,"name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication history"}},{"value":"This article has supporting information","name":"supplementary_materials","label":"Supplementary materials","explanation":{"URL":"https:\/\/scripts.iucr.org\/cgi-bin\/sendsup?vp3029"}},{"value":"\u00a9 Ziembicka\n                      et al.","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licensing","label":"Copyright and licencing"}},{"value":"IUCr licence to publish","order":1,"name":"license","label":"Licence","explanation":{"URL":"https:\/\/journals.iucr.org\/copyright\/licencetopublish.html"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}}]}}