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Complex\n                    <jats:bold>1<\/jats:bold>\n                    is a mononuclear complex in which the Zr\n                    <jats:sup>IV<\/jats:sup>\n                    atoms sit on the twofold axis and they are octacoordinated by two N and six O atoms of two tridentate anionic QCa\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ligands, and two aqua ligands. Outside the coordination sphere are two DMF molecules bound to the complex unit by hydrogen bonds. The structure and stability of complex\n                    <jats:bold>1<\/jats:bold>\n                    in dimethyl sulfoxide were verified by NMR spectroscopy. The cytotoxic properties of\n                    <jats:bold>1<\/jats:bold>\n                    and HQCaH were studied\n                    <jats:italic>in vitro<\/jats:italic>\n                    against eight cancer cell lines, and their selectivity was tested on the BJ-5ta noncancerous cell line. Both the complex and HQCaH exhibited low activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    &gt; 200\u2005\u00b5\n                    <jats:italic>M<\/jats:italic>\n                    . DNA and human serum albumin (HSA) binding studies showed that\n                    <jats:bold>1<\/jats:bold>\n                    binds to calf thymus (CT) DNA\n                    <jats:italic>via<\/jats:italic>\n                    intercalation and is able to bind to the tryptophan binding site of HSA (Trp-214).\n                  <\/jats:p>","DOI":"10.1107\/s2053229623005971","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:04:12Z","timestamp":1689077052000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":1,"title":["Low-dimensional compounds containing bioactive ligands. XXII. First crystal structure, cytotoxic activity and DNA and HSA binding of a zirconium(IV) complex with 8-hydroxyquinoline-2-carboxylic acid"],"prefix":"10.1107","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8439-925X","authenticated-orcid":true,"given":"Michaela","family":"Harmo\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Vilkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-5799","authenticated-orcid":true,"given":"Martin","family":"Kello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Smolko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Samol'ov\u00e1","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yhj4v17","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-1824","authenticated-orcid":true,"given":"Dominika","family":"\u0160ebov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-8816","authenticated-orcid":true,"given":"Ivan","family":"Poto\u010d\u0148\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"dg3041_bb1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10060930","volume":"10","author":"Arena","year":"2020","journal-title":"Biomolecules"},{"key":"dg3041_bb2","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/anie.199515551","volume":"34","author":"Bernstein","year":"1995","journal-title":"Angew. 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