{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:59:31Z","timestamp":1785401971549,"version":"3.56.0"},"reference-count":36,"publisher":"International Union of Crystallography (IUCr)","issue":"12","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"accepted":{"date-parts":[[2023,10,30]]},"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>\n                    Two new 2-(pyridin-2-yl)-1\n                    <jats:italic>H<\/jats:italic>\n                    -benzimidazole derivatives, namely, 2-(4-phenoxypyridin-2-yl)-1\n                    <jats:italic>H<\/jats:italic>\n                    -benzimidazole, C\n                    <jats:sub>18<\/jats:sub>\n                    H\n                    <jats:sub>13<\/jats:sub>\n                    N\n                    <jats:sub>3<\/jats:sub>\n                    O, and 2-[4-(4-fluorophenoxy)pyridin-2-yl]-1\n                    <jats:italic>H<\/jats:italic>\n                    -benzimidazole, C\n                    <jats:sub>18<\/jats:sub>\n                    H\n                    <jats:sub>12<\/jats:sub>\n                    FN\n                    <jats:sub>3<\/jats:sub>\n                    O, were synthesized and characterized by NMR spectroscopy. Crystal structure, biological activity and ADME analyses were performed for these two new compounds and a third compound, namely, 5,6-dimethyl-2-[4-(4-phenylpiperazin-1-yl)pyridin-2-yl]-1\n                    <jats:italic>H<\/jats:italic>\n                    -benzimidazole methanol monosolvate, C\n                    <jats:sub>24<\/jats:sub>\n                    H\n                    <jats:sub>25<\/jats:sub>\n                    N\n                    <jats:sub>5<\/jats:sub>\n                    \u00b7CH\n                    <jats:sub>3<\/jats:sub>\n                    OH, the synthesis of which had been described previously. All three compounds have a similar chain hydrogen-bonding pattern. One of them (the fluorophenoxy derivative) showed good antimicrobial activity against Gram-positive bacteria. The ADME analysis indicates that the compounds could be good drug candidates.\n                  <\/jats:p>","DOI":"10.1107\/s2053229623009452","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:19:35Z","timestamp":1698826775000},"page":"504-512","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":4,"title":["Structures and biological activity of three 2-(pyridin-2-yl)-1\n                    <i>H<\/i>\n                    -benzimidazole derivatives"],"prefix":"10.1107","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-7586","authenticated-orcid":true,"given":"Jaros\u0142aw","family":"Sukiennik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-1767","authenticated-orcid":true,"given":"Andrzej","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Gobis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Korona-G\u0142owniak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016f61126","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Su\u015bniak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016f61126","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-5596","authenticated-orcid":true,"given":"Andrzej","family":"Fruzi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Szczesio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"ef3049_bb1","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1016\/j.sjbs.2021.06.084","volume":"28","author":"Alarjani","year":"2021","journal-title":"Saudi J. 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