{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:11:00Z","timestamp":1756573860677,"version":"3.33.0"},"reference-count":13,"publisher":"International Union of Crystallography (IUCr)","issue":"3","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"accepted":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>A salt of vandetanib, namely, 4-({4-[(4-bromo-2-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}methoxy)-1-methylpiperazin-1-ium 2-(butylamino)-4-phenoxy-6-sulfamoylbenzoate acetonitrile monosolvate, C<jats:sub>22<\/jats:sub>H<jats:sub>25<\/jats:sub>BrFN<jats:sub>4<\/jats:sub>O<jats:sub>2<\/jats:sub>\n                  <jats:sup>+<\/jats:sup>\u00b7C<jats:sub>17<\/jats:sub>H<jats:sub>19<\/jats:sub>N<jats:sub>2<\/jats:sub>O<jats:sub>5<\/jats:sub>S<jats:sup>\u2212<\/jats:sup>\u00b7C<jats:sub>2<\/jats:sub>H<jats:sub>3<\/jats:sub>N, composed of kinase inhibitor vandetanib and sulfamyl diuretic bumetanide in a 1:1 molar ratio, is reported. There is proton transfer between the piperidine ring of vandetanib and the carboxyl group of bumetanide to form the salt. In the vandetanib cation, the arene and pyrimidine rings are not coplanar, their planes subtending a dihedral angle of 60.47\u2005(14)\u00b0. The roles of the intermolecular interactions in the crystal packing were clarified using Hirshfeld surface analysis, and two-dimensional fingerprint plots indicate that the most important contributions to the crystal packing are from H...H (40.5%), O...H\/H...C (20.7%), C...H\/ H...C (18.8%) and N...C\/C...N (9.0%) contacts.<\/jats:p>","DOI":"10.1107\/s2053229624000676","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T15:39:57Z","timestamp":1707320397000},"page":"62-65","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":2,"title":["Crystal structure and Hirshfeld surface analysis of a salt of antineoplastic kinase inhibitor vandetanib"],"prefix":"10.1107","volume":"80","author":[{"given":"Haiwu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"dg3049_bb1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1021\/acs.cgd.7b00531","volume":"17","author":"Allu","year":"2017","journal-title":"Cryst. 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University of Western Australia. https:\/\/crystalexplorer.net\/."},{"key":"dg3049_bb13","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1107\/S0021889810022120","volume":"43","author":"Westrip","year":"2010","journal-title":"J. Appl. 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