{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:08:44Z","timestamp":1785431324686,"version":"3.56.0"},"reference-count":27,"publisher":"International Union of Crystallography (IUCr)","issue":"11","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Action Medical Research\/LifeArc","award":["GN3039"],"award-info":[{"award-number":["GN3039"]}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","award":["EP\/Y014596\/1"],"award-info":[{"award-number":["EP\/Y014596\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"accepted":{"date-parts":[[2025,10,3]]},"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    Salcaprozate sodium (SNAC) is a clinically approved oral permeation enhancer, notably used in the formulation of oral semaglutide. Despite its pharmaceutical importance, the crystallographic information of SNAC or its free acid form, salcaprozoic acid {systematic name: 8-[(2-hydroxyphenyl)formamido]octanoic acid, C\n                    <jats:sub>15<\/jats:sub>\n                    H\n                    <jats:sub>21<\/jats:sub>\n                    NO\n                    <jats:sub>4<\/jats:sub>\n                    , denoted HNAC}, has not been reported previously. Here, we present the first crystallographic and physicochemical characterization of HNAC using single-crystal X-ray diffraction and complementary analytical techniques. The structure reveals the molecular conformation, hydrogen-bonding network and packing features of HNAC, supported by a complementary solid-state dataset. These findings provide fundamental insights into the structural and physicochemical properties of this physiologically relevant form of SNAC.\n                  <\/jats:p>","DOI":"10.1107\/s2053229625008691","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:57:16Z","timestamp":1759564636000},"page":"607-613","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Crystallographic and physicochemical characterization of salcaprozoic acid: a structural basis for SNAC-enabled drug delivery systems"],"prefix":"10.1107","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-3148","authenticated-orcid":true,"given":"Parag","family":"Roy","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01kj2bm70","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-7347","authenticated-orcid":true,"given":"Paul G.","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajdeep","family":"Dey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0232f6165","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ois\u00edn N.","family":"Kavanagh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01kj2bm70","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"vp3046_bb1","doi-asserted-by":"crossref","first-page":"o2117","DOI":"10.1107\/S1600536811029175","volume":"67","author":"Betz","year":"2011","journal-title":"Acta Cryst. 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