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Recrystallization of this substance from an ethanol\u2013acetonitrile (1:1\n                    <jats:italic>v<\/jats:italic>\n                    \/\n                    <jats:italic>v<\/jats:italic>\n                    ) mixture afforded disodium valsartan 2.67-hydrate ethanol 0.33-solvate, [Na\n                    <jats:sub>2<\/jats:sub>\n                    (C\n                    <jats:sub>24<\/jats:sub>\n                    H\n                    <jats:sub>27<\/jats:sub>\n                    N\n                    <jats:sub>5<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    )(C\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>5<\/jats:sub>\n                    OH)\n                    <jats:sub>0.33<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)\n                    <jats:sub>2.67<\/jats:sub>\n                    ]\n                    <jats:sub>\n                      <jats:italic>n<\/jats:italic>\n                    <\/jats:sub>\n                    (\n                    <jats:bold>2<\/jats:bold>\n                    ), with partially occupied ethanol and water positions. The crystal structure of\n                    <jats:bold>2<\/jats:bold>\n                    was studied using synchrotron radiation and refined as a two-component twin. The solids were found to be isotypical with four cations and two anions occupying equivalent positions (\n                    <jats:italic>Z<\/jats:italic>\n                    \u2032 = 2). The difference in the number of solvent molecules affects the coordination environment of Na2 and Na3 (Na2NO\n                    <jats:sub>5<\/jats:sub>\n                    and Na3NO\n                    <jats:sub>5<\/jats:sub>\n                    in\n                    <jats:bold>1<\/jats:bold>\n                    , and NaNO\n                    <jats:sub>4<\/jats:sub>\n                    \/NaNO\n                    <jats:sub>5<\/jats:sub>\n                    for both atoms in\n                    <jats:bold>2<\/jats:bold>\n                    due to solvent disorder), while two other sodium ions maintain the NaN\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    coordination. Valsartan acts as a dianion with both tetrazolyl and carboxyl groups deprotonated. The anions interact with sodium cations through the carboxyl, tetrazolyl and oxo groups as both bridging and bridging\u2013chelating ligands. Bridging anions and water molecules connect both structures into infinite two-dimensional layers. The surface of these layers is hydrophobic due to the coating of alkyl and aryl groups. Numerous O\u2014H...O and O\u2014H...N hydrogen bonds are observed within the layers.\n                  <\/jats:p>","DOI":"10.1107\/s2053229625010216","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:59:51Z","timestamp":1763726391000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Two isotypical disodium salts of the antihypertensive agent valsartan"],"prefix":"10.1107","volume":"82","author":[{"given":"Petr A.","family":"Buikin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-9886","authenticated-orcid":true,"given":"Alexander A.","family":"Korlyukov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03jzs4815","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-3614","authenticated-orcid":true,"given":"Pavel V.","family":"Dorovatovskii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-303X","authenticated-orcid":true,"given":"Anna V.","family":"Vologzhanina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03jzs4815","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"vx3019_bb1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.ccr.2005.03.031","volume":"249","author":"Alvarez","year":"2005","journal-title":"Coord. 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