{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:54:26Z","timestamp":1790938466284,"version":"4.1.0"},"reference-count":29,"publisher":"International Union of Crystallography (IUCr)","issue":"9","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1U01AI187033-01"],"award-info":[{"award-number":["1U01AI187033-01"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"accepted":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    We report the first crystal structure of the telmisartan\u2013tempol conjugate 2,2,6,6-tetramethyl-1-(\u03bb\u2032-oxidaneyl)piperidin-4-yl 4\u2032-[(1,7\u2032-dimethyl-2\u2032-propyl-1\n                    <jats:italic>H<\/jats:italic>\n                    ,3\u2032\n                    <jats:italic>H<\/jats:italic>\n                    -[2,5\u2032-bibenzo[\n                    <jats:italic>d<\/jats:italic>\n                    ]imidazol]-3\u2032-yl)methyl]-[1,1\u2032-biphenyl]-2-carboxylate free radical (YK-4-250, C\n                    <jats:sub>42<\/jats:sub>\n                    H\n                    <jats:sub>46<\/jats:sub>\n                    N\n                    <jats:sub>5<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT\n                    <jats:sub>1<\/jats:sub>\n                    R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).\n                  <\/jats:p>","DOI":"10.1107\/s2053229626007242","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:40:41Z","timestamp":1784536841000},"page":"547-552","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["YK-4-250, a synthetic telmisartan\u2013tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT\n                    <sub>1<\/sub>\n                    receptor inhibitor"],"prefix":"10.1107","volume":"82","author":[{"given":"Simon","family":"Friedrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Kong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zjtrb98","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faik N.","family":"Musayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton L.","family":"Brown","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zjtrb98","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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