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Structural analysis showed that TTCA adopts two principal supramolecular motifs: the hydrogen-bonded\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    (8) dimer and linear chain assemblies. Two dominant drug\u2013coformer binding schemes were identified. The first involves N\u2014H...N hydrogen bonding in the\n                    <jats:italic>para<\/jats:italic>\n                    position relative to the TTCA dimer, leading to four-molecule assemblies, which are accompanied by heteronuclear hydrogen bonding in the\n                    <jats:italic>ortho<\/jats:italic>\n                    position. The second motif is associated with TTCA linear chains, where drug molecules are linked through N\u2014H...N interactions and further stabilized by direct intermolecular or solvent-mediated hydrogen bonding. The polymorphic structure 2RNZ\u00b72TTCA combines both supramolecular strategies within a single-crystal architecture. Hirshfeld surface analysis and intermolecular energy calculations confirmed the importance of hydrogen-bond competition in determining the crystal packing and supramolecular organization in TTCA-based cocrystals.\n                  <\/jats:p>","DOI":"10.1107\/s2053229626008156","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:34:05Z","timestamp":1786617245000},"page":"562-575","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Multicomponent crystals of nitroimidazole drugs with trithiocyanuric acid: two competing drug\u2013coformer supramolecular motifs"],"prefix":"10.1107","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9970-1404","authenticated-orcid":true,"given":"Valeryia","family":"Hushcha","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cq64r17","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-7011","authenticated-orcid":true,"given":"Agnieszka. 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