{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:26:12Z","timestamp":1790241972222,"version":"4.1.0"},"reference-count":35,"publisher":"International Union of Crystallography (IUCr)","issue":"3","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/uk\/legalcode"},{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/uk\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr F Struct Biol Commun","Acta Crystallogr F","Acta Crystallogr F Struct Biol Cryst Commun","Acta Cryst F","Acta Cryst F Struct Biol Commun","Acta Cryst Sect F","Acta Cryst Sect F Struct Biol Commun","Acta Crystallogr Sect F","Acta Crystallogr Sect F Struct Biol Commun","Acta Crystallogr Sect F Struct Biol Cryst Commun"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:p>\n                    The rapid spread of the recent\n                    <jats:italic>Zika virus<\/jats:italic>\n                    (ZIKV) epidemic across various countries in the American continent poses a major health hazard for the unborn fetuses of pregnant women. To date, there is no effective medical intervention. The nonstructural protein 5 of\n                    <jats:italic>Zika virus<\/jats:italic>\n                    (ZIKV-NS5) is critical for ZIKV replication through the 5\u2032-RNA capping and RNA polymerase activities present in its N-terminal methyltransferase (MTase) and C-terminal RNA-dependent RNA polymerase (RdRp) domains, respectively. The crystal structure of the full-length ZIKV-NS5 protein has been determined at 3.05\u2005\u00c5 resolution from a crystal belonging to space group\n                    <jats:italic>P<\/jats:italic>\n                    2\n                    <jats:sub>1<\/jats:sub>\n                    2\n                    <jats:sub>1<\/jats:sub>\n                    2 and containing two protein molecules in the asymmetric unit. The structure is similar to that reported for the NS5 protein from\n                    <jats:italic>Japanese encephalitis virus<\/jats:italic>\n                    and suggests opportunities for structure-based drug design targeting either its MTase or RdRp domain.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x17001601","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T10:40:04Z","timestamp":1487673604000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":97,"title":["Crystal structure of full-length\n                    <i>Zika virus<\/i>\n                    NS5 protein reveals a conformation similar to\n                    <i>Japanese encephalitis virus<\/i>\n                    NS5"],"prefix":"10.1107","volume":"73","author":[{"given":"Anup K.","family":"Upadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-4300","authenticated-orcid":true,"given":"Matthew","family":"Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton","family":"Longenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale J.","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"tt5093_bb1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ejmech.2016.10.007","volume":"125","author":"Benmansour","year":"2017","journal-title":"Eur. 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