{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:15:25Z","timestamp":1782231325648,"version":"3.54.5"},"reference-count":50,"publisher":"International Union of Crystallography (IUCr)","issue":"9","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"funder":[{"DOI":"10.13039\/100012728","name":"Frederick National Laboratory for Cancer Research","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100012728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health, National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr F Struct Biol Commun","Acta Crystallogr F","Acta Crystallogr F Struct Biol Cryst Commun","Acta Cryst F","Acta Cryst F Struct Biol Commun","Acta Cryst Sect F","Acta Cryst Sect F Struct Biol Commun","Acta Crystallogr Sect F","Acta Crystallogr Sect F Struct Biol Commun","Acta Crystallogr Sect F Struct Biol Cryst Commun"],"accepted":{"date-parts":[[2019,8,9]]},"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    , the causative agent of bubonic plague, is one of the most lethal pathogens in recorded human history. Today, the concern is the possible misuse of\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    as an agent in bioweapons and bioterrorism. Current therapies for the treatment of plague include the use of a small number of antibiotics, but clinical cases of antibiotic resistance have been reported in some areas of the world. Therefore, the discovery of new drugs is required to combat potential\n                    <jats:italic>Y.\u00a0pestis<\/jats:italic>\n                    infection. Here, the crystal structure of the\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    UDP-glucose pyrophosphorylase (UGP), a metabolic enzyme implicated in the survival of\n                    <jats:italic>Y.\u00a0pestis<\/jats:italic>\n                    in mouse macrophages, is described at 2.17\u2005\u00c5 resolution. The structure provides a foundation that may enable the rational design of inhibitors and open new avenues for the development of antiplague therapeutics.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x19011154","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T12:14:42Z","timestamp":1566994482000},"page":"608-615","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":5,"title":["Crystal structure of UDP-glucose pyrophosphorylase from\n                    <i>Yersinia pestis<\/i>\n                    , a potential therapeutic target against plague"],"prefix":"10.1107","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-1939","authenticated-orcid":true,"given":"Morgan E.","family":"Gibbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-8881","authenticated-orcid":true,"given":"George T.","family":"Lountos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Gumpena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Waugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"rf5020_bb1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1107\/S0907444912001308","volume":"68","author":"Afonine","year":"2012","journal-title":"Acta Cryst. 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