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A series of virulence factors secreted by <jats:italic>S. aureus<\/jats:italic> can trigger severe diseases such as sepsis, endocarditis and toxic shock, and thus have a great impact on human health. The transformation of <jats:italic>S. aureus<\/jats:italic> from a colonization state to a pathogenic state during its life cycle is intimately associated with the initiation of bacterial aggregation and biofilm accumulation. SdrC, an <jats:italic>S. aureus<\/jats:italic> surface protein, can act as an adhesin to promote cell attachment and aggregation by an unknown mechanism. Here, structural studies demonstrate that SdrC forms a unique dimer through intermolecular interaction. It is proposed that the dimerization of SdrC enhances the efficiency of bacteria\u2013host attachment and therefore contributes to the pathogenicity of <jats:italic>S. aureus<\/jats:italic>.<\/jats:p>","DOI":"10.1107\/s2053230x21000741","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T15:45:34Z","timestamp":1612280734000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":8,"title":["Structural insights into the intermolecular interaction of the adhesin SdrC in the pathogenicity of <i>Staphylococcus aureus<\/i>"],"prefix":"10.1107","volume":"77","author":[{"given":"Junchao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianye","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianrong","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"ft5112_bb2","doi-asserted-by":"crossref","first-page":"e1000726","DOI":"10.1371\/journal.ppat.1000726","volume":"6","author":"Barbu","year":"2010","journal-title":"PLoS Pathog."},{"key":"ft5112_bb3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/mmi.12750","volume":"94","author":"Barbu","year":"2014","journal-title":"Mol. 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