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SODs are consequently protective against oxidative damage to cellular components. Among other protective mechanisms, the filarial parasite\n                    <jats:italic>Onchocerca volvulus<\/jats:italic>\n                    has a well developed defense system to scavenge toxic free radicals using SODs during migration and sojourning of the microfilariae and adult worms in the human body.\n                    <jats:italic>O. volvulus<\/jats:italic>\n                    is responsible for the neglected disease onchocerciasis or `river blindness'. In the present study, an extracellular Cu\/Zn-SOD from\n                    <jats:italic>O. volvulus<\/jats:italic>\n                    (\n                    <jats:italic>Ov<\/jats:italic>\n                    EC-SOD) was cloned, purified and crystallized to obtain structural insight into an attractive drug target with the potential to combat onchocerciasis. The recombinant\n                    <jats:italic>Ov<\/jats:italic>\n                    EC-SOD forms a dimer and the protein structure was solved and refined to 1.55\u2005\u00c5 resolution by X-ray crystallography. Interestingly, a sulfate ion supports the coordination of the conserved copper ion. The overall protein shape was verified by small-angle X-ray scattering. The enzyme shows a different surface charge distribution and different termini when compared with the homologous human SOD. A distinct hydrophobic cleft to which both protomers of the dimer contribute was utilized for a docking approach with compounds that have previously been identified as SOD inhibitors to highlight the potential for individual structure-based drug development.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x22005350","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T09:40:59Z","timestamp":1653644459000},"page":"232-240","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":1,"title":["Crystal structure of an extracellular superoxide dismutase from\n                    <i>Onchocerca volvulus<\/i>\n                    and implications for parasite-specific drug development"],"prefix":"10.1107","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-6457","authenticated-orcid":true,"given":"Amr","family":"Moustafa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g30e956","id-type":"ROR","asserted-by":"publisher"}],"department":["Laboratory for Structural Biology of Infection and Inflammation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Perbandt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g30e956","id-type":"ROR","asserted-by":"publisher"}],"department":["Laboratory for Structural Biology of Infection and Inflammation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Liebau","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"publisher"}],"department":["Institut f\u00fcr Zoophysiologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Betzel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g30e956","id-type":"ROR","asserted-by":"publisher"}],"department":["Laboratory for Structural Biology of Infection and Inflammation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3409-1791","authenticated-orcid":true,"given":"Sven","family":"Falke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g30e956","id-type":"ROR","asserted-by":"publisher"}],"department":["Laboratory for Structural Biology of Infection and Inflammation"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"no5193_bb1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/bbrc.1997.7777","volume":"241","author":"Ascone","year":"1997","journal-title":"Biochem. 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