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Human TRMT2A has also been described as a modifier of polyglutamine (polyQ)-derived neuronal toxicity. The corresponding human polyQ pathologies include Huntington's disease and constitute a family of devastating neurodegenerative diseases. A polyQ tract in the corresponding disease-linked protein causes neuronal death and symptoms such as impaired motor function, as well as cognitive impairment. In polyQ disease models, silencing of TRMT2A reduced polyQ-associated cell death and polyQ protein aggregation, suggesting this protein as a valid drug target against this class of disorders. In this paper, the 1.6\u2005\u00c5 resolution crystal structure of the RNA-recognition motif (RRM) from\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , which is a homolog of human TRMT2A, is described and analysed.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x24000645","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:15:51Z","timestamp":1705922151000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Crystal structure of the RNA-recognition motif of\n                    <i>Drosophila melanogaster<\/i>\n                    tRNA (uracil-5-)-methyltransferase homolog A"],"prefix":"10.1107","volume":"80","author":[{"given":"Monika","family":"Witzenberger","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"department":["Institute of Structural Biology, Molecular Targets and Therapeutics Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Janowski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"department":["Institute of Structural Biology, Molecular Targets and Therapeutics Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dierk","family":"Niessing","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"department":["Institute of Structural Biology, Molecular Targets and Therapeutics Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"ek5035_bb40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1107\/S2059798323003595","volume":"79","author":"Agirre","year":"2023","journal-title":"Acta Cryst. 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