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It has been extensively studied by biochemical and structural techniques. 13 X-ray crystal structures and five electron cryo-microscopy structures in the PDB are focused on in this topical review. Two F\n                    <jats:sub>420<\/jats:sub>\n                    -dependent glucose-6-phosphate dehydrogenase (FGD) structures are also reported. The significant differences between human and parasite G6PDs can be exploited to\u00a0find selective drugs against infections such as malaria and leishmaniasis. Furthermore, G6PD is a prognostic marker in several cancer types and is also considered to be a tumour target. On the other hand, FGD is considered to be a target against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    and possesses a high biotechnological potential in biocatalysis and bioremediation.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x24008112","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:05:00Z","timestamp":1725267900000},"page":"236-251","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":4,"title":["Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microscopy"],"prefix":"10.1107","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-9941","authenticated-orcid":true,"given":"Stefania","family":"Hanau","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/041zkgm14","id-type":"ROR","asserted-by":"publisher"}],"department":["Department of Neuroscience and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-7540","authenticated-orcid":true,"given":"John R.","family":"Helliwell","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"va5059_bb1","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1016\/S0021-9258(20)81975-9","volume":"258","author":"Adams","year":"1983","journal-title":"J. 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