{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:21:53Z","timestamp":1785410513226,"version":"3.56.0"},"reference-count":0,"publisher":"International Union of Crystallography (IUCr)","issue":"12","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93022C00036"],"award-info":[{"award-number":["75N93022C00036"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U01GM138433"],"award-info":[{"award-number":["U01GM138433"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-SC0012704"],"award-info":[{"award-number":["DE-SC0012704"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD030394"],"award-info":[{"award-number":["S10OD030394"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr F Struct Biol Commun","Acta Crystallogr F","Acta Crystallogr F Struct Biol Cryst Commun","Acta Cryst F","Acta Cryst F Struct Biol Commun","Acta Cryst Sect F","Acta Cryst Sect F Struct Biol Commun","Acta Crystallogr Sect F","Acta Crystallogr Sect F Struct Biol Commun","Acta Crystallogr Sect F Struct Biol Cryst Commun"],"accepted":{"date-parts":[[2024,10,30]]},"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p>\n                    <jats:italic>Onchocerca volvulus<\/jats:italic>\n                    causes blindness, onchocerciasis, skin infections and devastating neurological diseases such as nodding syndrome. New treatments are needed because the currently used drug, ivermectin, is contraindicated in pregnant women and those co-infected with\n                    <jats:italic>Loa loa<\/jats:italic>\n                    . The Seattle Structural Genomics Center for Infectious Disease (SSGCID) produced, crystallized and determined the apo structure of N-terminally hexahistidine-tagged\n                    <jats:italic>O. volvulus<\/jats:italic>\n                    macrophage migration inhibitory factor-1 (His-\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1).\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1 is a possible drug target. His-\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1 has a unique jellyfish-like structure with a prototypical macrophage migration inhibitory factor (MIF) trimer as the `head' and a unique C-terminal `tail'. Deleting the N-terminal tag reveals an\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1 structure with a larger cavity than that observed in human MIF that can be targeted for drug repurposing and discovery. Removal of the tag will be necessary to determine the actual biological oligomer of\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1 because size-exclusion chomatographic analysis of His-\n                    <jats:italic>Ov<\/jats:italic>\n                    MIF-1 suggests a monomer, while\n                    <jats:italic>PISA<\/jats:italic>\n                    analysis suggests a hexamer stabilized by the unique C-terminal tails.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x24010550","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:56:48Z","timestamp":1730717808000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":4,"title":["Crystal structure of N-terminally hexahistidine-tagged\n                    <i>Onchocerca volvulus<\/i>\n                    macrophage migration inhibitory factor-1"],"prefix":"10.1107","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-1596","authenticated-orcid":true,"given":"Amber D.","family":"Kimble","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gt1vc06","id-type":"ROR","asserted-by":"publisher"}],"department":["Department of Clinical Laboratory Science, College of Nursing and Allied Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1616-5969","authenticated-orcid":true,"given":"Omolara C. 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Kimble\n                      et al.","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}},{"value":"Creative Commons Attribution (CC-BY)","order":1,"name":"license","label":"Licence","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}}]}}