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Triosephosphate isomerase (TPI) is a glycolytic enzyme that has been researched as a drug target for various parasites, including\n                    <jats:italic>F. hepatica<\/jats:italic>\n                    . The high-resolution crystal structure of\n                    <jats:italic>F.\u00a0hepatica<\/jats:italic>\n                    TPI (\n                    <jats:italic>Fh<\/jats:italic>\n                    TPI) has been solved at 1.51\u2005\u00c5 resolution in its monoclinic form. The structure has been used to perform molecular-docking studies with the most successful fasciolocide triclabendazole (TCBZ), which has recently been suggested to target\n                    <jats:italic>Fh<\/jats:italic>\n                    TPI. Two\n                    <jats:italic>Fh<\/jats:italic>\n                    TPI residues, Lys50 and Asp51, are located at the dimer interface and are found in close proximity to the docked TCBZ. These residues are not conserved in mammalian hosts.\n                  <\/jats:p>","DOI":"10.1107\/s2053230x25006454","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T14:39:17Z","timestamp":1753454357000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Triosephosphate isomerase from\n                    <i>Fasciola hepatica<\/i>\n                    : high-resolution crystal structure as a drug target"],"prefix":"10.1107","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-3544","authenticated-orcid":true,"given":"Georgios","family":"Kontellas","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yghzc09","id-type":"ROR","asserted-by":"publisher"}],"department":["Henry Wellcome Building for Biocatalysis, Biosciences, Faculty of Health and Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-6637","authenticated-orcid":true,"given":"David J.","family":"Studholme","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yghzc09","id-type":"ROR","asserted-by":"publisher"}],"department":["Biosciences, Faculty of Health and Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-1335","authenticated-orcid":true,"given":"Mark","family":"van der Giezen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yghzc09","id-type":"ROR","asserted-by":"publisher"}],"department":["Biosciences, Faculty of Health and Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-8818","authenticated-orcid":true,"given":"David J.","family":"Timson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04kp2b655","id-type":"ROR","asserted-by":"publisher"}],"department":["School of Pharmacy and Biomolecular Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-3986","authenticated-orcid":true,"given":"Jennifer A.","family":"Littlechild","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yghzc09","id-type":"ROR","asserted-by":"publisher"}],"department":["Henry Wellcome Building for Biocatalysis, Biosciences, Faculty of Health and Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-4289","authenticated-orcid":true,"given":"Michail N.","family":"Isupov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yghzc09","id-type":"ROR","asserted-by":"publisher"}],"department":["Henry Wellcome Building for Biocatalysis, Biosciences, Faculty of Health and Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ir5049_bb1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1107\/S2059798323003595","volume":"79","author":"Agirre","year":"2023","journal-title":"Acta Cryst. 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