{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T08:49:54Z","timestamp":1736844594039,"version":"3.33.0"},"reference-count":10,"publisher":"International Union of Crystallography (IUCr)","issue":"6","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0\/uk\/legalcode"},{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0\/uk\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2017,5,17]]},"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:p>The title compound, C<jats:sub>28<\/jats:sub>H<jats:sub>32<\/jats:sub>N<jats:sub>2<\/jats:sub>, (I), is one of a second generation of compounds designed and synthesized based on a very potent and selective \u03b19\u03b110 nicotinic acetylcholine receptor antagonist ZZ161C {1,1\u2032-[[1,1\u2032-biphenyl]-4,4\u2032-diylbis(prop-2-yne-3,1-diyl)]bis(3,4-dimethylpyridin-1-ium) bromide}, which has shown analgesic effects in a chemotherapy-induced neuropathy animal model. Compound (I) was synthesized by the reaction of 4,4\u2032-bis(3-bromoprop-1-yn-1-yl)-1,1\u2032-biphenyl with piperidine at room temperature in acetonitrile. The single-crystal used for X-ray analysis was obtained by dissolving (I) in a mixture of dichloromethane and methanol, followed by slow evaporation of the solvent. In the crystal of (I), the biphenyl moiety has a twisted conformation, with a dihedral angle of 25.93\u2005(4)\u00b0 between the benzene rings. Both piperidine head groups in (I) are in the chair conformation and are oriented so that the N-atom lone pairs of each piperidine group point away from the central biphenyl moiety.<\/jats:p>","DOI":"10.1107\/s2056989017007277","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T08:36:49Z","timestamp":1495183009000},"page":"864-866","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Crystal structure of 4,4\u2032-bis[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1\u2032-biphenyl"],"prefix":"10.1107","volume":"73","author":[{"given":"Anqi","family":"Walbaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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