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The multi-component solvated Lopinavir crystal, systematic name (2<jats:italic>S<\/jats:italic>)-<jats:italic>N<\/jats:italic>-[(2<jats:italic>S<\/jats:italic>,4<jats:italic>S<\/jats:italic>,5<jats:italic>S<\/jats:italic>)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide\u2013ethane-1,2-diol\u2013water (8\/3\/7) 8C<jats:sub>37<\/jats:sub>H<jats:sub>48<\/jats:sub>N<jats:sub>4<\/jats:sub>O<jats:sub>5<\/jats:sub>\u00b73C<jats:sub>2<\/jats:sub>H<jats:sub>6<\/jats:sub>O<jats:sub>2<\/jats:sub>\u00b77H<jats:sub>2<\/jats:sub>O, was prepared using evaporative methods. The crystalline material obtained from this experimental synthesis was characterized and elucidated by single-crystal X-ray diffraction (SC-XRD). The crystal structure is unusual in that the unit cell contains 18 molecules. The stoichiometric ratio of this crystal is eight Lopinavir molecules [8(C<jats:sub>37<\/jats:sub>H<jats:sub>48<\/jats:sub>N<jats:sub>4<\/jats:sub>O<jats:sub>5<\/jats:sub>)], three ethane-1,2-diol molecules [3(C<jats:sub>2<\/jats:sub>H<jats:sub>6<\/jats:sub>O<jats:sub>2<\/jats:sub>)] and seven water molecules [7(H<jats:sub>2<\/jats:sub>O)]. The crystal packing features both bi- and trifurcated hydrogen bonds between atoms.<\/jats:p>","DOI":"10.1107\/s2056989024004158","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T07:14:55Z","timestamp":1729754095000},"page":"1206-1209","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Structural multiplicity in a solvated hydrate of the antiretroviral protease inhibitor Lopinavir"],"prefix":"10.1107","volume":"80","author":[{"given":"Tebogo M. 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