{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:59:59Z","timestamp":1785423599235,"version":"3.56.0"},"reference-count":18,"publisher":"International Union of Crystallography (IUCr)","issue":"10","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2024,9,11]]},"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>\n                    The crystal structure of the title compound C\n                    <jats:sub>20<\/jats:sub>\n                    H\n                    <jats:sub>17<\/jats:sub>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    S features hydrogen-bonding and C\u2014H...\u03c0 interactions. Hirshfeld surface analysis revealed that H...H, C...H\/H...C and O...H\/H...O interactions make a major contribution to the crystal packing. Docking studies were carried out to determine the binding affinity and interaction profile of the title compound with EGFR kinase, a member of the ErbB family of receptor tyrosine kinases, which is crucial for processes such as cell proliferation and differentiation. The title compound shows a strong binding affinity with EGFR kinase, with the most favourable conformation having a binding energy of \u22128.27 kcal mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    and a predicted IC50 of 870.34 n\n                    <jats:italic>M<\/jats:italic>\n                    , indicating its potential as a promising candidate for targeted lung cancer therapy.\n                  <\/jats:p>","DOI":"10.1107\/s2056989024008892","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T03:51:18Z","timestamp":1726458678000},"page":"1034-1038","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Crystal structure and Hirshfeld surface analysis of (\n                    <i>E<\/i>\n                    )-\n                    <i>N<\/i>\n                    -(2-styrylphenyl)benzenesulfonamide"],"prefix":"10.1107","volume":"80","author":[{"given":"Dharani","family":"Albert A. 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M.\n                      et al.","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}},{"value":"Creative Commons Attribution (CC-BY)","order":1,"name":"license","label":"Licence","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}}]}}