{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:13:39Z","timestamp":1736226819302,"version":"3.32.0"},"reference-count":33,"publisher":"International Union of Crystallography (IUCr)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2024,11,28]]},"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p>Two novel complexes, [Cu(<jats:bold>T4<\/jats:bold>)Cl<jats:sub>2<\/jats:sub>] and [Zn(<jats:bold>T4<\/jats:bold>)Cl<jats:sub>2<\/jats:sub>], were synthesized from 1,1\u2032-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-<jats:italic>a<\/jats:italic>]pyridine] (<jats:bold>T4<\/jats:bold>), and copper(II) and zinc(II) chloride, respectively. The structures of these complexes were confirmed using ESI-MS, IR and <jats:sup>1<\/jats:sup>H NMR spectra. The results reveal mononuclear structures in which the central metal atoms are coordinated by two N atoms from the imidazole rings and two Cl ligands. The structure of the <jats:bold>CuT4<\/jats:bold> complex [systematic name: dichlorido{1,1\u2032-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-<jats:italic>a<\/jats:italic>]pyridine]-\u03ba<jats:sup>2<\/jats:sup>\n                  <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032}copper(II), [CuCl<jats:sub>2<\/jats:sub>(C<jats:sub>33<\/jats:sub>H<jats:sub>21<\/jats:sub>F<jats:sub>3<\/jats:sub>N<jats:sub>4<\/jats:sub>)], was confirmed by single-crystal X-ray diffraction. The Cu<jats:sup>II<\/jats:sup> atom adopts a distorted tetrahedral coordination environment with an N<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> coordination set. The predominant features of the crystal packing are C\u2014H...F, C\u2014H...\u03c0 and C\u2014F...\u03c0 interactions. Biological evaluations demonstrated that both complexes exhibit enhanced anticancer activity compared to the free ligand, with IC<jats:sub>50<\/jats:sub> values ranging between 18.93 and 67.06\u2005\u00b5<jats:italic>M<\/jats:italic>. Notably, the Cu<jats:sup>II<\/jats:sup> complex displays excellent inhibitory activity against the MCF7 breast cancer cell line (IC<jats:sub>50<\/jats:sub> = 27.99\u2005\u00b5<jats:italic>M<\/jats:italic>), approximately twice as effective as cisplatin. Conversely, the <jats:bold>ZnT4<\/jats:bold> complex shows greater efficacy against Hep-G2 and A549 lung cancer cell lines, with IC<jats:sub>50<\/jats:sub> values between 18.93 and 24.83\u2005\u00b5<jats:italic>M<\/jats:italic>. The results suggest that Cu<jats:sup>II<\/jats:sup> and Zn<jats:sup>II<\/jats:sup> complexes of <jats:bold>T4<\/jats:bold> show potential as cancer treatment agents.<\/jats:p>","DOI":"10.1107\/s2056989024011617","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T08:26:57Z","timestamp":1734078417000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Syntheses, structures and anticancer activities of Cu<sup>II<\/sup> and Zn<sup>II<\/sup> complexes containing 1,1\u2032-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-<i>a<\/i>]pyridine]"],"prefix":"10.1107","volume":"81","author":[{"given":"Hai","family":"Le Thi Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau","family":"Nguyen Van","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Hoang Tuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung","family":"Tran Quang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan","family":"Dang Thanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-5209","authenticated-orcid":true,"given":"Luc","family":"Van Meervelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"wm5742_bb21","doi-asserted-by":"crossref","first-page":"100556","DOI":"10.1016\/j.jics.2022.100556","volume":"99","author":"Agarwal","year":"2022","journal-title":"J. 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