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A short intramolecular S...O contact of 2.5992\u2005(4)\u2005\u00c5 is observed. The amide NH<jats:sub>2<\/jats:sub> group is planar, whereas the amine NH<jats:sub>2<\/jats:sub> group is pyramidalized. The three-dimensional packing involves two interconnected layer structures. The first, parallel to the <jats:italic>bc<\/jats:italic> plane, involves three classical hydrogen bonds N\u2014H<jats:sub>amine<\/jats:sub>...O (one of two), N\u2014H<jats:sub>amine<\/jats:sub>...Cl and one N\u2014H<jats:sub>amide<\/jats:sub> ...N<jats:sub>cyano<\/jats:sub>; the second, parallel to the <jats:italic>ab<\/jats:italic> plane, involves two hydrogen bonds, N\u2014H<jats:sub>amide<\/jats:sub>...O and the second N\u2014H<jats:sub>amine<\/jats:sub>...O, together with the short and linear contact N<jats:sub>cyano<\/jats:sub>...Cl\u2014C, which may be regarded as a halogen bond.<\/jats:p>","DOI":"10.1107\/s2056989025001562","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T08:32:59Z","timestamp":1741077179000},"page":"279-283","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":3,"title":["Crystal structure of 1-amino-3-(4-chlorophenyl)-2-cyano-3<i>H<\/i>-benzo[4,5]thiazolo[3,2-<i>a<\/i>]pyridine-4-carboxamide"],"prefix":"10.1107","volume":"81","author":[{"given":"Nadia H.","family":"Metwally","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galal H.","family":"Elgemeie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-shimaa S. 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