{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:44:53Z","timestamp":1785437093537,"version":"3.56.0"},"reference-count":25,"publisher":"International Union of Crystallography (IUCr)","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2025,3,19]]},"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>\n                    In the title compound, C\n                    <jats:sub>13<\/jats:sub>\n                    H\n                    <jats:sub>13<\/jats:sub>\n                    ClN\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    \u00b7H\n                    <jats:sub>2<\/jats:sub>\n                    O, the organic molecule has an\n                    <jats:italic>E<\/jats:italic>\n                    configuration with regard to the C=N bond of the hydrazone bridge. The phenyl and pyridazine rings subtend a dihedral angle of 2.1\u2005(1)\u00b0 between their mean planes, while the hydrazone moiety makes dihedral angles of 1.6\u2005(2) and 3.0\u2005(2)\u00b0, respectively, with these aromatic rings. This renders the entire molecule comparably flat. A C\u2014H...N hydrogen bond generates an inversion dimer with a large\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    (14) ring motif. Within this ring, a further C\u2014H...N hydrogen bond establishes a smaller\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2<\/jats:sup>\n                    (8) ring. The molecules of a dimer are thereby firmly linked by four hydrogen bonds. A bifurcated O\u2014H...(O,O) hydrogen bond is formed between a water hydrogen atom and the hydroxyl and methoxy oxygen atoms of an adjacent molecule, leading to the formation of an\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>1<\/jats:sup>\n                    (5) membered ring. C\u2014H...\u03c0 and face-to-face \u03c0\u2013\u03c0 stacking interactions are also present in the two-dimensional framework, which may be of relevance for the packing. In a complementary analysis, the compound was docked\n                    <jats:italic>in silico<\/jats:italic>\n                    to EGFR and HER2 receptors and the results imply that the compound targets EGFR preferentially over HER2.\n                  <\/jats:p>","DOI":"10.1107\/s205698902500252x","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:55:06Z","timestamp":1742788506000},"page":"336-340","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, crystal structure, and\n                    <i>in silico<\/i>\n                    molecular docking studies of 4-hydroxy-3,5-dimethoxybenzaldehyde (6-chloropyridazin-3-yl)hydrazone monohydrate"],"prefix":"10.1107","volume":"81","author":[{"given":"Muhammed Rafi","family":"Ummer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jmt9361","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"NizamMohideen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jmt9361","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Nazrudeen","family":"Noorulla","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jmt9361","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abubacker Sidhik","family":"Moolan Khaja","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jmt9361","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"yz2065_bb1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/14756360903155781","volume":"25","author":"Ahmad","year":"2010","journal-title":"J. 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