{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:40:09Z","timestamp":1743759609318,"version":"3.40.3"},"reference-count":25,"publisher":"International Union of Crystallography (IUCr)","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2025,3,21]]},"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>The decapeptide Boc-(D-Phe-tFPro-Val-Leu-Leu)<jats:sub>2<\/jats:sub>\u2014OMe (<jats:bold>1<\/jats:bold>) (Boc is <jats:italic>tert<\/jats:italic>-butoxycarbonyl, tFPro is 4-<jats:italic>trans<\/jats:italic>-fluoro-L-proline D-Phe is D-phenylalanine, Val is valine and Leu is leucine) crystallized in a methanol-solvated form (C<jats:sub>68<\/jats:sub>H<jats:sub>104<\/jats:sub>F<jats:sub>2<\/jats:sub>N<jats:sub>10<\/jats:sub>O<jats:sub>13<\/jats:sub>\u00b7CH<jats:sub>4<\/jats:sub>O). Peptide <jats:bold>1<\/jats:bold> has a sequence similar to gramicidin S (GS) incorporating tFPro. GS is a cyclic peptide, with the D-Phe-Pro unit known as a strong \u03b2-turn inducer in previous studies. Thus, it was initially assumed that <jats:bold>1<\/jats:bold> would bend at the D-Phe6-tFPro7 position, potentially forming a sheet-like structure. However, the structure of <jats:bold>1<\/jats:bold> was a helix, a surprising finding in GS-related structural studies. A factor enabling this helical formation could be the fluorine\u2013H interactions between tFPro and the aromatic rings of D-Phe residues.<\/jats:p>","DOI":"10.1107\/s2056989025002592","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:23:43Z","timestamp":1743063823000},"page":"345-349","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Fluorine\u2013hydrogen interactions observed in a helix structure having an orn-free gramicidin S sequence incorporating 4-<i>trans<\/i>-fluoroproline"],"prefix":"10.1107","volume":"81","author":[{"given":"Asano","family":"Akiko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kato","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-828X","authenticated-orcid":true,"given":"Mitsunobu","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ox2013_bb2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2116\/xraystruct.35.1","volume":"35","author":"Asano","year":"2019","journal-title":"X-ray Struct. 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