{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:17Z","timestamp":1785412517163,"version":"3.56.0"},"reference-count":19,"publisher":"International Union of Crystallography (IUCr)","issue":"8","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Fitchurg State University Special Projects Grant"},{"name":"Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health","award":["2P20GM103432"],"award-info":[{"award-number":["2P20GM103432"]}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2025,7,16]]},"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    The title compound, C\n                    <jats:sub>17<\/jats:sub>\n                    H\n                    <jats:sub>16<\/jats:sub>\n                    F\n                    <jats:sub>6<\/jats:sub>\n                    N\n                    <jats:sub>2<\/jats:sub>\n                    O\u00b7CH\n                    <jats:sub>3<\/jats:sub>\n                    OH, is composed of a quinolinyl group and a piperidinyl group connected\n                    <jats:italic>via<\/jats:italic>\n                    a hydroxymethine (\u2013CHOH) functionality. The compound, which is monosolvated by methanol, was crystallized\n                    <jats:italic>via<\/jats:italic>\n                    slow evaporation of a methanol solution, yielding colorless prism-like crystals. The hydroxymethine center of the compound is in the absolute\n                    <jats:italic>R<\/jats:italic>\n                    configuration, whereas the chiral center of the piperidinyl ring is in the\n                    <jats:italic>S<\/jats:italic>\n                    configuration. The conformation of the piperidinyl ring is a chair. The supramolecular architecture of the crystal is sustained by a set of hydrogen bonds: O\u2014H...O, N\u2014H...O and C\u2014H...F. The intermolecular forces are further analyzed and confirmed by a Hirshfeld surface analysis. DFT structural data computed with the\n                    <jats:italic>ORCA<\/jats:italic>\n                    quantum chemistry program package using the B3LYP\/def2-TZVPP basis set compare quite well with the experimental X-ray crystal structural data.\n                  <\/jats:p>","DOI":"10.1107\/s2056989025006310","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T14:47:12Z","timestamp":1752763632000},"page":"718-722","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Crystal structure and Hirshfeld surface analysis of [(\n                    <i>R<\/i>\n                    ,\n                    <i>S<\/i>\n                    )-2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol methanol monosolvate"],"prefix":"10.1107","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2899-8410","authenticated-orcid":true,"given":"Dennis","family":"Awasabisah","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/031tt0491","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navamoney","family":"Arulsamy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01485tq96","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7761-455X","authenticated-orcid":true,"given":"Mason","family":"Primrose","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/031tt0491","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"yz2068_bb1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11243-023-00563-6","volume":"49","author":"Awasabisah","year":"2024","journal-title":"Transit. Met. Chem."},{"key":"yz2068_bb2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1107\/S0108767394005726","volume":"51","author":"Blessing","year":"1995","journal-title":"Acta Cryst. A"},{"key":"yz2068_bb3","unstructured":"Bruker (2019). SAINT. Bruker AXS Inc., Madison, Wisconsin, USA."},{"key":"yz2068_bb4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1107\/S0108768102003324","volume":"58","author":"Bruno","year":"2002","journal-title":"Acta Cryst. B"},{"key":"yz2068_bb5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cplu.201300074","volume":"78","author":"Dassonville-Klimpt","year":"2013","journal-title":"ChemPlusChem"},{"key":"yz2068_bb6","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1021\/jm400282d","volume":"56","author":"Gorka","year":"2013","journal-title":"J. Med. 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Cryst."},{"key":"yz2068_bb12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/wcms.81","volume":"2","author":"Neese","year":"2012","journal-title":"WIREs Comput. Mol. Sci."},{"key":"yz2068_bb13","doi-asserted-by":"crossref","unstructured":"Neese, F. (2022). WIREs Comput. Mol. Sci. 12, e1606.","DOI":"10.1002\/wcms.1606"},{"key":"yz2068_bb14","doi-asserted-by":"crossref","first-page":"224108","DOI":"10.1063\/5.0004608","volume":"152","author":"Neese","year":"2020","journal-title":"J. Chem. Phys."},{"key":"yz2068_bb15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. C"},{"key":"yz2068_bb16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. 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