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The Cu\n                    <jats:sup>II<\/jats:sup>\n                    ions adopt a square-pyramidal environment with the basal plane comprising one chloride ion and the organic ligand acting as the N,N,S-donor bis-chelate tridentate group. The second chloride ion resides in the apical position and it completes the electrically neutral complex. The supramolecular landscape is dominated by conventional hydrogen bonding involving strong hydrogen-bond donors and acceptors [O(N)H...O and O(N)H...Cl], which assemble the complex units and solvent water molecules into bilayers parallel to the\n                    <jats:italic>bc<\/jats:italic>\n                    plane. The primary significance of the contacts with H atoms was assessed with the results of Hirshfeld analysis, which suggest a 51.3% contribution of such contacts to the surface of individual complex molecules. The relatively short chalcogenide bonds [S...O = 3.006\u2005(2)\u2005\u00c5] and NH\n                    <jats:sub>2<\/jats:sub>\n                    (guanidine)-\u03c0 interactions are also relevant to the packing. The chemical identity of\n                    <jats:bold>1<\/jats:bold>\n                    and the bulk sample is confirmed by elemental analysis, IR spectroscopic and thermogravimetric data.\n                  <\/jats:p>","DOI":"10.1107\/s2056989026003804","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:07:47Z","timestamp":1776409667000},"page":"494-499","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["A serendipitous product of the reaction of famotidine with copper(II)"],"prefix":"10.1107","volume":"82","author":[{"given":"Aylen","family":"Grenni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-3098","authenticated-orcid":true,"given":"Javier","family":"Ellena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-2694","authenticated-orcid":true,"given":"Gianella","family":"Facchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"nu2017_bb1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","author":"Addison","year":"1984","journal-title":"J. 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