{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:21:09Z","timestamp":1778070069761,"version":"3.51.4"},"reference-count":14,"publisher":"International Union of Crystallography (IUCr)","issue":"5","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2026,4,10]]},"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    The structure of nirmatrelvir MTBE solvate, C\n                    <jats:sub>23<\/jats:sub>\n                    H\n                    <jats:sub>32<\/jats:sub>\n                    F\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>5<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \u00b7C\n                    <jats:sub>5<\/jats:sub>\n                    H\n                    <jats:sub>12<\/jats:sub>\n                    O, at 150\u2005K has monoclinic (\n                    <jats:italic>P<\/jats:italic>\n                    2\n                    <jats:sub>1<\/jats:sub>\n                    ) symmetry. The asymmetric unit contains one nirmatrelvir molecule and one methyl\n                    <jats:italic>tert<\/jats:italic>\n                    -butyl ether solvent molecule. The extended structure consists of N\u2014H...O hydrogen bonds that create create [010] chains. Crystals of the title compound were grown from various methyl\n                    <jats:italic>tert<\/jats:italic>\n                    -butyl ether\u2013methanol solvent mixtures, with crystal morphology dependent upon the mixture ratio.\n                  <\/jats:p>","DOI":"10.1107\/s2056989026003816","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:38:06Z","timestamp":1775835486000},"page":"477-479","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Nirmatrelvir methyl\n                    <i>tert<\/i>\n                    -butyl ether solvate"],"prefix":"10.1107","volume":"82","author":[{"given":"Jared P.","family":"Smit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale K.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Engers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley C.","family":"Bauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Radocea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"jy2071_bb1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. 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