{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:59:50Z","timestamp":1786118390045,"version":"build-2736575974"},"reference-count":0,"publisher":"International Union of Crystallography (IUCr)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr E Cryst Commun","Acta Cryst E","Acta Cryst Sect E","Acta Crystallogr E","Acta Crystallogr Sect E","Acta Cryst E Cryst Commun","Acta Cryst Sect E Cryst Commun"],"accepted":{"date-parts":[[2026,7,23]]},"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    Cocrystallization of norfloxacin (NFX) with three heterocyclic coformers, namely, pyridine-3,5-dicarboxylic acid, pyridazine-3-carboxylic acid and pyrimidine-5-carboxylic acid, yielded three molecular salts: norfloxacinium [4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium] 5-carboxypyridine-3-carboxylate trihydrate, 2C\n                    <jats:sub>16<\/jats:sub>\n                    H\n                    <jats:sub>19<\/jats:sub>\n                    FN\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    \u00b72C\n                    <jats:sub>7<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    NO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b73H\n                    <jats:sub>2<\/jats:sub>\n                    O, (\n                    <jats:bold>1<\/jats:bold>\n                    ), norfloxacinium pyridazine-3-carboxylate, C\n                    <jats:sub>16<\/jats:sub>\n                    H\n                    <jats:sub>19<\/jats:sub>\n                    FN\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    \u00b7C\n                    <jats:sub>5<\/jats:sub>\n                    H\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    , (\n                    <jats:bold>2<\/jats:bold>\n                    ), and norfloxacinium pyrimidine-5-carboxylate monohydrate, C\n                    <jats:sub>16<\/jats:sub>\n                    H\n                    <jats:sub>19<\/jats:sub>\n                    FN\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    \u00b7C\n                    <jats:sub>5<\/jats:sub>\n                    H\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b7H\n                    <jats:sub>2<\/jats:sub>\n                    O, (\n                    <jats:bold>3<\/jats:bold>\n                    ). In all structures, the quinolone skeleton of the norfloxacin cation is essentially planar, while the piperazine ring adopts a chair conformation. The crystal packing is governed primarily by N\u2014H...O and N\u2014H...N hydrogen bonds, which generate distinct mono-periodic and di-periodic motifs depending on the coformer. These assemblies are further linked by weak C\u2014H...O and C\u2014H...N interactions into tri-periodic supramolecular networks. The crystal structures are additionally stabilized by aromatic \u03c0\u2013\u03c0 interactions, which differ in their stacking arrangements among the three salts. Hirshfeld surface analysis of the norfloxacin cations shows that H...H and O...H\/H...O contacts dominate, whereas variations in the contributions from C...C, C...H\/H...C and N...H\/H...N contacts reflect differences in the supramolecular packing.\n                  <\/jats:p>","DOI":"10.1107\/s2056989026007589","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:17:17Z","timestamp":1785485837000},"page":"985-991","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Structural characterization of three norfloxacin salts with N-heterocyclic mono- and dicarboxylic acids"],"prefix":"10.1107","volume":"82","author":[{"given":"Anna","family":"Ben","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cq64r17","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9970-1404","authenticated-orcid":true,"given":"Valeryia","family":"Hushcha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cq64r17","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-920X","authenticated-orcid":true,"given":"Lilianna","family":"Ch\u0119ci\u0144ska","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cq64r17","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2026,7,31]]},"container-title":["Acta Crystallographica Section E Crystallographic 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(CC-BY)","order":1,"name":"license","label":"Licence","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}}]}}