{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:48:43Z","timestamp":1791413323950,"version":"4.3.3"},"reference-count":49,"publisher":"International Union of Crystallography (IUCr)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr D Struct Biol","Acta Crystallogr D","Acta Cryst D","Acta Cryst D Struct Biol","Acta Cryst Sect D","Acta Cryst Sect D Struct Biol","Acta Crystallogr Sect D","Acta Crystallogr Sect D Struct Biol","Acta Crystallogr D Biol Crystallogr","Acta Cryst D Biol Cryst"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>The<jats:italic>Filoviridae<\/jats:italic>family of negative-sense, single-stranded RNA (ssRNA) viruses is comprised of two species of<jats:italic>Marburgvirus<\/jats:italic>(MARV and RAVV) and five species of<jats:italic>Ebolavirus<\/jats:italic>,<jats:italic>i.e.<\/jats:italic>Zaire (EBOV), Reston (RESTV), Sudan (SUDV), Ta\u00ef Forest (TAFV) and Bundibugyo (BDBV). In each of these viruses the ssRNA encodes seven distinct proteins. One of them, the nucleoprotein (NP), is the most abundant viral protein in the infected cell and within the viral nucleocapsid. It is tightly associated with the viral RNA in the nucleocapsid, and during the lifecycle of the virus is essential for transcription, RNA replication, genome packaging and nucleocapsid assembly prior to membrane encapsulation. The structure of the unique C-terminal globular domain of the NP from EBOV has recently been determined and shown to be structurally unrelated to any other known protein [Dziuba\u0144ska<jats:italic>et al.<\/jats:italic>(2014),<jats:italic>Acta Cryst<\/jats:italic>. D<jats:bold>70<\/jats:bold>, 2420\u20132429]. In this paper, a study of the C-terminal domains from the NP from the remaining four species of<jats:italic>Ebolavirus<\/jats:italic>, as well as from the MARV strain of<jats:italic>Marburgvirus<\/jats:italic>, is reported. As expected, the crystal structures of the BDBV and TAFV proteins show high structural similarity to that from EBOV, while the MARV protein behaves like a molten globule with a core residual structure that is significantly different from that of the EBOV protein.<\/jats:p>","DOI":"10.1107\/s2059798315021439","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T15:44:30Z","timestamp":1450453470000},"page":"49-58","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":18,"title":["Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses"],"prefix":"10.1107","volume":"72","author":[{"given":"Laura E.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Ellena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna B.","family":"Handing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Derewenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darkhan","family":"Utepbergenov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zygmunt S.","family":"Derewenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"gm5041_bb1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Cryst. 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