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Bacterial substrate-binding proteins (SBPs) bind iron\u2013siderophore complexes and deliver these complexes to ATP-binding cassette (ABC) transporters for import into the cytoplasm, where the iron can be transferred from the siderophore to catalytic enzymes. In<jats:italic>Yersinia pestis<\/jats:italic>, the causative agent of plague, the<jats:italic>Yersinia<\/jats:italic>iron-uptake (Yiu) ABC transporter has been shown to improve iron acquisition under iron-chelated conditions. The Yiu transporter has been proposed to be an iron\u2013siderophore transporter; however, the precise siderophore substrate is unknown. Therefore, the precise role of the Yiu transporter in<jats:italic>Y. pestis<\/jats:italic>survival remains uncharacterized. To better understand the function of the Yiu transporter, the crystal structure of YiuA (YPO1310\/y2875), an SBP which functions to present the iron\u2013siderophore substrate to the transporter for import into the cytoplasm, was determined. The 2.20 and 1.77\u2005\u00c5 resolution X-ray crystal structures reveal a basic triad binding motif at the YiuA canonical substrate-binding site, indicative of a metal-chelate binding site. Structural alignment and computational docking studies support the function of YiuA in binding chelated metal. Additionally, YiuA contains two mobile helices, helix 5 and helix 10, that undergo 2\u20133\u2005\u00c5 shifts across crystal forms and demonstrate structural breathing of the c-clamp architecture. The flexibility in both c-clamp lobes suggest that YiuA substrate transfer resembles the Venus flytrap mechanism that has been proposed for other SBPs.<\/jats:p>","DOI":"10.1107\/s2059798317015236","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T16:49:27Z","timestamp":1509036567000},"page":"921-939","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":8,"title":["The crystal structure of the<i>Yersinia pestis<\/i>iron chaperone YiuA reveals a basic triad binding motif for the chelated metal"],"prefix":"10.1107","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-7710","authenticated-orcid":true,"given":"Christopher D.","family":"Radka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-5342","authenticated-orcid":true,"given":"Dongquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-1013","authenticated-orcid":true,"given":"Lawrence J.","family":"DeLucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-5534","authenticated-orcid":true,"given":"Stephen G.","family":"Aller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"jm5030_bb1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Cryst. 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