{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:38:54Z","timestamp":1764103134212,"version":"3.37.3"},"reference-count":20,"publisher":"International Union of Crystallography (IUCr)","issue":"6","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100006348","name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla","doi-asserted-by":"crossref","award":["100317000-VIEP2018"],"award-info":[{"award-number":["100317000-VIEP2018"]}],"id":[{"id":"10.13039\/501100006348","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["304678","429355","268178"],"award-info":[{"award-number":["304678","429355","268178"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["IUCrData","IUCr Data","International Union Crystallogr Data","Int Union Cryst Data"],"accepted":{"date-parts":[[2020,6,10]]},"published-print":{"date-parts":[[2020,6,28]]},"abstract":"<jats:p>The title compound, C<jats:sub>22<\/jats:sub>H<jats:sub>33<\/jats:sub>NO<jats:sub>12<\/jats:sub>\u00b7CHCl<jats:sub>3<\/jats:sub>, was obtained as a product of a double aza-Michael addition of hydroxylamine on a Chiron with a known absolute configuration. The enantiopure compound crystallized as a chloroform solvate, in space group <jats:italic>P<\/jats:italic>1, and diffraction data were collected at room temperature with Ag <jats:italic>K<\/jats:italic>\u03b1 radiation. The Flack parameter refined to <jats:italic>x<\/jats:italic> = \u22120.01\u2005(16); however, the Flack and Watkin 2<jats:italic>AD<\/jats:italic> plot clearly shows that differences between Friedel opposites (the <jats:italic>D<\/jats:italic> component of the plot) do not carry any reliable information about resonant scattering of Cl atoms, and are rather dominated by random and systematic errors. The <jats:italic>R<jats:sub>D<\/jats:sub>\n                  <\/jats:italic> factor calculated using 1941 acentric Friedel pairs is <jats:italic>R<jats:sub>D<\/jats:sub>\n                  <\/jats:italic> = 0.995. On the other hand, the 2<jats:italic>A<\/jats:italic> component of the plot, related to average intensities of Friedel pairs, shows that data are of good quality (<jats:italic>R<jats:sub>A<\/jats:sub>\n                  <\/jats:italic> = 0.069). This example illustrates that while using Ag <jats:italic>K<\/jats:italic>\u03b1 radiation (\u03bb = 0.56083\u2005\u00c5), scatterers heavier than Cl should be present in a chiral crystal in order to determine confidently the absolute structure of the crystal.<\/jats:p>","DOI":"10.1107\/s2414314620007889","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T08:08:00Z","timestamp":1592294880000},"update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":1,"title":["Ethyl (3<i>S<\/i>)-3-[(3a<i>R<\/i>,5<i>R<\/i>,6<i>S<\/i>,6a<i>R<\/i>)-6-hydroxy-2,2-dimethyltetrahydrofuro[4,5-<i>d<\/i>][1,3]dioxol-5-yl]-3-{(3<i>S<\/i>)-3-[(3a<i>R<\/i>,5<i>R<\/i>,6<i>S<\/i>,6a<i>R<\/i>)-6-hydroxy-2,2-dimethyltetrahydrofuro[4,5-<i>d<\/i>][1,3]dioxol-5-yl]-5-oxoisoxazolidin-2-yl}propanoate chloroform monosolvate"],"prefix":"10.1107","volume":"5","author":[{"given":"Aldo Guillermo","family":"Amaro Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasa","family":"Rodr\u00edguez Tzompantzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"D\u00e1vila Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-9921","authenticated-orcid":true,"given":"Rosa Luisa","family":"Meza-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9209-7580","authenticated-orcid":true,"given":"Sylvain","family":"Bern\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"bx4018_bb1","unstructured":"Amaro Hern\u00e1ndez, A. 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