{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:21:31Z","timestamp":1785424891697,"version":"3.56.0"},"reference-count":12,"publisher":"International Union of Crystallography (IUCr)","issue":"5","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Howard University College of Medicine","award":["Project U100272, Fund 19, Program 02"],"award-info":[{"award-number":["Project U100272, Fund 19, Program 02"]}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["2U54MD007597"],"award-info":[{"award-number":["2U54MD007597"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000086","name":"National Science Foundation, Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["NSF MRI grant (DMR-2117502) for the X-ray diffractometer"],"award-info":[{"award-number":["NSF MRI grant (DMR-2117502) for the X-ray diffractometer"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["IUCrData","IUCr Data","International Union Crystallogr Data","Int Union Cryst Data"],"accepted":{"date-parts":[[2025,5,23]]},"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:p>\n                    The structure of the title compound, [CdCl\n                    <jats:sub>2<\/jats:sub>\n                    (C\n                    <jats:sub>15<\/jats:sub>\n                    H\n                    <jats:sub>16<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    S)], at 100\u2005K has monoclinic (\n                    <jats:italic>P<\/jats:italic>\n                    2\n                    <jats:sub>1<\/jats:sub>\n                    \/\n                    <jats:italic>c<\/jats:italic>\n                    ) symmetry. The compound has a layer structure and is a 1:1 complex of the organic ligand and cadmium chloride. The ligand, 3,3-dimethyl-1-[(\n                    <jats:italic>E<\/jats:italic>\n                    )-[phenyl(pyridine-2-yl)methylidene]amino]thiourea (\n                    <jats:italic>L<\/jats:italic>\n                    , Bp44mT), is of interest with respect to anticancer activity, antiviral properties and potential use in conditions of iron overload, from hemochromatosis or from multiple transfusions in hematological disorders such as sickle cell disease or beta thalassemia. This study is aimed at uncovering the basis of selectivity of the ligand as a chelator and for lead optimization. We also examine the ligand's potential use in treating heavy metal poisoning from cadmium, arsenic, lead or mercury, and for environmental remediation. The crystal structure exhibits no intermolecular or intramolecular hydrogen bonding with the supramolecular features being driven by hydrophobic, \u03c0\u2013\u03c0 and long-range dispersion forces.\n                  <\/jats:p>","DOI":"10.1107\/s241431462500464x","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:43:43Z","timestamp":1748324623000},"update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":0,"title":["Dichlorido{(\n                    <i>E<\/i>\n                    )-\n                    <i>N<\/i>\n                    ,\n                    <i>N<\/i>\n                    -dimethyl-2-[phenyl(pyridin-2-yl)methylidene]hydrazine-1-carbothioamide}cadmium(II)"],"prefix":"10.1107","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-5460","authenticated-orcid":true,"given":"Christian S.","family":"Parry","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Kwabi-Addo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-5445","authenticated-orcid":true,"given":"Timothy R.","family":"Ramadhar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Butcher","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"bt4171_bb1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1107\/S2053273314022207","volume":"71","author":"Bourhis","year":"2015","journal-title":"Acta Cryst. 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