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In addition, mean arterial blood pressure (MAP) is stabilized by means of a decoupling controller with automated noradrenaline (NA) dosage to ensure adequate systemic perfusion during ventilation therapy for patients with acute respiratory distress syndrome (ARDS).<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-heading\">Design\/methodology\/approach<\/jats:title><jats:p>\u2013 The aim is to develop an automatic control system for mechanical ventilation therapy based on the OLC using artificial intelligence. In addition, MAP is stabilized by means of a decoupling controller with automated NA dosage to ensure adequate systemic perfusion during ventilation therapy for patients with ARDS.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-heading\">Findings<\/jats:title><jats:p>\u2013 This innovative closed-loop mechanical ventilation system leads to a significant improvement in oxygenation, regulates end-tidal carbon dioxide for appropriate gas exchange and stabilizes MAP to guarantee proper systemic perfusion during the ventilation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-heading\">Research limitations\/implications<\/jats:title><jats:p>\u2013 Currently, this automatic ventilation system based on the OLC can only be applied in animal trials; for clinical use, such a system generally requires a mechanical ventilator and sensors with medical approval for humans.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-heading\">Practical implications<\/jats:title><jats:p>\u2013 For implementation of a closed-loop ventilation system, reliable signals from the sensors are a prerequisite for successful application.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-heading\">Originality\/value<\/jats:title><jats:p>\u2013 The experiment with porcine dynamics demonstrates the feasibility and usefulness of this automatic closed-loop ventilation therapy, with hemodynamic control for severe ARDS. Moreover, this pilot study validated a new algorithm for implementation of the OLC, whereby all control objectives are fulfilled during the ventilation therapy with adequate hemodynamic control of patients with ARDS.<\/jats:p><\/jats:sec>","DOI":"10.1108\/ijicc-05-2014-0025","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T10:52:20Z","timestamp":1426503140000},"page":"50-68","source":"Crossref","is-referenced-by-count":18,"title":["Artificial intelligence for closed-loop ventilation therapy with hemodynamic control using the open lung concept"],"prefix":"10.1108","volume":"8","author":[{"given":"Anake","family":"Pomprapa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danita","family":"Muanghong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"K\u00f6ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Leonhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Pickerodt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onno","family":"Tjarks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Schwaiberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Lachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"140","reference":[{"key":"key2020122600490490200_b1","doi-asserted-by":"crossref","unstructured":"Acute Respiratory Distress Syndrome Network. 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