{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:23:19Z","timestamp":1770355399701,"version":"3.49.0"},"reference-count":38,"publisher":"Emerald","issue":"6","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.emerald.com\/insight\/site-policies"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EC"],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:sec><jats:title content-type=\"abstract-subheading\">Purpose<\/jats:title><jats:p>Develop biodegradable meshes as a novel solution to address issues associated with using synthetic meshes for POP repair.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-subheading\">Design\/methodology\/approach<\/jats:title><jats:p>Computational models were created with variations in the pore geometry, pore size, filament thickness, and inclusion of filaments around specific mesh regions. Subsequently, one of the meshes was 3D printed to validate the results obtained from the simulations. Following this, a uniaxial tensile test was carried out on the vaginal tissue of a sow to compare with the simulations, to identify meshes that displayed behaviour akin to vaginal tissue. Finally, the most promising outcomes were compared with those of the uterosacral ligament and a commercially available mesh.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-subheading\">Findings<\/jats:title><jats:p>Following a comprehensive analysis of the results, the mesh that most accurately replicates the behaviour of the vaginal tissue showcases a smaller pore diameter (1.50\u00a0mm), filaments in specific areas of the mesh, and variable filament thickness across the mesh. Nevertheless, upon comparing the outcomes with those of the uterosacral, the meshes do not exhibit similar behaviour to the ligament. Finally, the commercially available mesh does not represent the behaviour of both the vaginal tissue and the uterosacral ligament and in this sense may not be the best treatment option for POP repair.<\/jats:p><\/jats:sec><jats:sec><jats:title content-type=\"abstract-subheading\">Originality\/value<\/jats:title><jats:p>Their biocompatibility and biomechanical properties make them a potential solution to the disadvantages of synthetic meshes. Personalized\/customized meshes could be part of the future of surgical POP repair.<\/jats:p><\/jats:sec>","DOI":"10.1108\/ec-12-2023-0967","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T22:10:22Z","timestamp":1718057422000},"page":"1399-1423","source":"Crossref","is-referenced-by-count":7,"title":["3D printing and development of\u00a0computational models of\u00a0biodegradable meshes for\u00a0pelvic\u00a0organ prolapse"],"prefix":"10.1108","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9793-4076","authenticated-orcid":false,"given":"Maria Francisca Reis Raba\u00e7a","family":"Vaz","sequence":"first","affiliation":[]},{"given":"Maria Elisabete","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Parente","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio Augusto","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"140","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"issue":"2","key":"key2024080105184567000_ref001","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.4041743","article-title":"Deformation of transvaginal mesh in response to multiaxial loading","volume":"141","year":"2019","journal-title":"Journal of Biomechanical Engineering"},{"issue":"3","key":"key2024080105184567000_ref002","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/membranes7030047","article-title":"Past, present and future of surgical meshes: a review","volume":"7","year":"2017","journal-title":"Membranes"},{"issue":"2","key":"key2024080105184567000_ref003","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00192-021-05018-z","article-title":"International urogynecology consultation chapter 1 committee 2: epidemiology of pelvic organ prolapse: prevalence, incidence, natural history, and service needs","volume":"33","year":"2022","journal-title":"International Urogynecology Journal"},{"key":"key2024080105184567000_ref040","unstructured":"Corbion (2019), Purasorb\u00ae DL - Product Specification Data Sheet, Issue September, pp. 1-2, available at: https:\/\/materials.ulprospector.com\/en\/document\/odm?tds&docid=211293"},{"key":"key2024080105184567000_ref005","article-title":"Optimisation of a MEW prototype for mesh implants fabrication","year":"2020"},{"key":"key2024080105184567000_ref006","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/3dp.2021.0010","article-title":"Melt electrospinning writing of mesh implants for pelvic organ prolapse repair","year":"2021","journal-title":"3D Printing and Additive Manufacturing"},{"issue":"5","key":"key2024080105184567000_ref007","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1089\/3dp.2021.0010","article-title":"Melt electrospinning writing of mesh implants for pelvic organ prolapse repair","volume":"9","year":"2022","journal-title":"3D Printing and Additive Manufacturing"},{"issue":"7","key":"key2024080105184567000_ref008","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s00192-021-05071-8","article-title":"Urinary and sexual impact of pelvic reconstructive surgery for genital prolapse by surgical route. A randomized controlled trial","volume":"33","year":"2022","journal-title":"International Urogynecology Journal"},{"issue":"1","key":"key2024080105184567000_ref009","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jobcr.2019.10.003","article-title":"Polycaprolactone as biomaterial for bone scaffolds: review of literature","volume":"10","year":"2020","journal-title":"Journal of Oral Biology and Craniofacial Research"},{"key":"key2024080105184567000_ref010","first-page":"118","article-title":"R econstructive S urgery of the T horacolumbar","volume":"51","year":"2002","journal-title":"Neurosurgery"},{"issue":"7","key":"key2024080105184567000_ref011","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.actbio.2010.02.002","article-title":"Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering","volume":"6","year":"2010","journal-title":"Acta Biomaterialia"},{"key":"key2024080105184567000_ref012","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ejogrb.2022.01.003","article-title":"Two-year anatomical and functional outcomes of laparoscopic sacrocolpopexy using light-weight Y shaped mesh for post hysterectomy vaginal prolapse","volume":"270","year":"2022","journal-title":"European Journal of Obstetrics and Gynecology and Reproductive Biology"},{"key":"key2024080105184567000_ref013","volume-title":"FDA Takes Action to Protect Women's Health, Orders Manufacturers of Surgical Mesh Intended for Transvaginal Repair of Pelvic Organ Prolapse to Stop Selling All Devices","author":"FDA","year":"2019"},{"issue":"11","key":"key2024080105184567000_ref014","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nmat3134","article-title":"Poisson's ratio and modern materials","volume":"10","year":"2011","journal-title":"Nature Materials"},{"issue":"1","key":"key2024080105184567000_ref015","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/biom12010094","article-title":"Role of fibroblasts and myofibroblasts on the pathogenesis and treatment of pelvic organ prolapse","volume":"12","year":"2022","journal-title":"Biomolecules"},{"issue":"5","key":"key2024080105184567000_ref016","first-page":"389","article-title":"Melt electrowriting prototype optimization for medical-grade polycaprolactone mesh printing","volume":"9","year":"2022","journal-title":"3D Printing and Additive Manufacturing"},{"issue":"1","key":"key2024080105184567000_ref017","doi-asserted-by":"publisher","first-page":"e2001232","DOI":"10.1002\/adhm.202001232","article-title":"Polymers for melt electrowriting","volume":"10","year":"2021","journal-title":"Advanced Healthcare Materials"},{"issue":"3","key":"key2024080105184567000_ref018","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/SPV.0b013e318254f09c.Patient","article-title":"Patient understanding of Pelvic floor disoders: what women Want to Know","volume":"18","year":"2012","journal-title":"Female Pelvic Medicine Reconstruction Surgery"},{"key":"key2024080105184567000_ref019","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/953209","article-title":"High structural stability of textile implants prevents pore collapse and preserves effective porosity at strain","volume":"2015","year":"2015","journal-title":"BioMed Research International"},{"issue":"5","key":"key2024080105184567000_ref020","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.4039058","article-title":"Preventing mesh pore collapse by designing mesh pores with auxetic geometries: a comprehensive evaluation via computational modeling","volume":"140","year":"2018","journal-title":"Journal of Biomechanical Engineering"},{"issue":"6","key":"key2024080105184567000_ref021","doi-asserted-by":"publisher","first-page":"413","DOI":"10.4111\/icu.2019.60.6.413","article-title":"Current surgical management of pelvic organ prolapse: strategies for the improvement of surgical outcomes","volume":"60","year":"2019","journal-title":"Investigative and Clinical Urology"},{"key":"key2024080105184567000_ref022","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2022.896719","article-title":"Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering","volume":"10","year":"2022","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"621","key":"key2024080105184567000_ref023","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.abd5758","article-title":"Importance of the pig as a human biomedical model","volume":"13","year":"2021","journal-title":"Science Translational Medicine"},{"issue":"3","key":"key2024080105184567000_ref024","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00192-020-04612-x","article-title":"Comparison of synthetic mesh erosion and chronic pain rates after surgery for pelvic organ prolapse and stress urinary incontinence: a systematic review","volume":"32","year":"2021","journal-title":"International Urogynecology Journal"},{"issue":"13","key":"key2024080105184567000_ref025","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1039\/d2bm00179a","article-title":"Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction","volume":"10","year":"2022","journal-title":"Biomaterials Science"},{"key":"key2024080105184567000_ref026","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/B978-008044463-5\/50016-9","article-title":"Activated carbon (origins)","year":"2006","journal-title":"Activated Carbon"},{"issue":"3-4","key":"key2024080105184567000_ref027","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0045-7825(97)00162-X","article-title":"Computer methods in applied mechaaics end englneerlng A numerical model of passive and active behavior of skeletal muscles","volume":"151","year":"1998","journal-title":"Computer methods in applied mechanics and engineering"},{"issue":"2","key":"key2024080105184567000_ref028","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00404-012-2564-3","article-title":"Strength of round and uterosacral ligaments: a biomechanical study","volume":"287","year":"2013","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"15","key":"key2024080105184567000_ref029","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.3390\/app10155289","article-title":"Experimental characterization and finite element modeling of the effects of 3D bioplotting process parameters on structural and tensile properties of polycaprolactone (PCL) scaffold","volume":"10","year":"2020","journal-title":"Applied Sciences"},{"key":"key2024080105184567000_ref030","volume-title":"Uniaxial Testing","year":"2023"},{"issue":"4","key":"key2024080105184567000_ref031","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/polym14040763","article-title":"Development of 3D printed biodegradable mesh with antimicrobial properties for pelvic organ prolapse","volume":"14","year":"2022","journal-title":"Polymers"},{"key":"key2024080105184567000_ref032","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4036396","article-title":"Characterisation of polycaprolactone scaffolds made by melt electrospinning writing for pelvic organ prolapse correction- a Pilot study","year":"2022","journal-title":"SSRN Electronic Journal"},{"key":"key2024080105184567000_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110649","article-title":"Effect of mesh anchoring technique in uterine prolapse repair surgery: a finite element analysis","volume":"127","year":"2021","journal-title":"Journal of Biomechanics"},{"issue":"4","key":"key2024080105184567000_ref034","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1177\/09544119221074567","article-title":"Simulation of vaginal uterosacral ligament suspension damage, mimicking a mesh-augmented apical prolapse repair","volume":"236","year":"2022","journal-title":"Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine"},{"issue":"2","key":"key2024080105184567000_ref035","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3390\/surgeries3020012","article-title":"Cog threads for transvaginal prolapse repair: ex-vivo studies of a novel concept","volume":"3","year":"2022","journal-title":"Surgeries"},{"key":"key2024080105184567000_ref036","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/app.54687","article-title":"Development of new surgical mesh geometries with different mechanical properties using the design freedom of 3D printing","volume":"140","year":"2023","journal-title":"Journal of Applied Polymer Science"},{"issue":"2","key":"key2024080105184567000_ref037","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ejogrb.2009.03.004","article-title":"Rate, type, and cost of pelvic organ prolapse surgery in Germany, France, and England","volume":"144","year":"2009","journal-title":"European Journal of Obstetrics and Gynecology and Reproductive Biology"},{"issue":"16","key":"key2024080105184567000_ref038","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1080\/10255842.2016.1186662","article-title":"3D finite element modeling of pelvic organ prolapse","volume":"19","year":"2016","journal-title":"Computer Methods in Biomechanics and Biomedical Engineering"}],"container-title":["Engineering Computations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.emerald.com\/insight\/content\/doi\/10.1108\/EC-12-2023-0967\/full\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.emerald.com\/insight\/content\/doi\/10.1108\/EC-12-2023-0967\/full\/html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T01:22:35Z","timestamp":1753406555000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.emerald.com\/ec\/article\/41\/6\/1399-1423\/1236007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,13]]},"published-print":{"date-parts":[[2024,8,2]]}},"alternative-id":["10.1108\/EC-12-2023-0967"],"URL":"https:\/\/doi.org\/10.1108\/ec-12-2023-0967","relation":{},"ISSN":["0264-4401"],"issn-type":[{"value":"0264-4401","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,13]]}}}