{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:25:47Z","timestamp":1777627547545,"version":"3.51.4"},"reference-count":111,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR1412500"],"award-info":[{"award-number":["17ZR1412500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18dz2271000"],"award-info":[{"award-number":["18dz2271000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1109\/access.2019.2949415","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T19:54:55Z","timestamp":1571946895000},"page":"155002-155013","source":"Crossref","is-referenced-by-count":20,"title":["Recognizing Novel Tumor Suppressor Genes Using a Network Machine Learning Strategy"],"prefix":"10.1109","volume":"7","author":[{"given":"Ran","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-1583","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Han","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-4097","authenticated-orcid":false,"given":"Shuaiqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Aorigele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz041"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby028"},{"key":"ref33","first-page":"1137","article-title":"A study of cross-validation and bootstrap for accuracy estimation and model selection","author":"kohavi","year":"1995","journal-title":"Proc Int Joint Conf Artif Intell"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2174\/1386207319666161227124350"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2017.2661756"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00019"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty140"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2174\/1570164616666190126103036"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90109-9"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz757"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-016-1240-x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2018.09.010"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1021\/pr100618t"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00205"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1959-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx043"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.02.013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2944177"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290058"},{"key":"ref26","first-page":"3133","article-title":"Do we need hundreds of classifiers to solve real world classification problems?","volume":"15","author":"fern\u00e1ndez-delgado","year":"2014","journal-title":"J Mach Learn Res"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.06.012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.019"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1038\/ng.936"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.050"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0925-7"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.06.001"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2270"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4428"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1038\/sj.onc.1207386","article-title":"Bone morphogenetic protein-5, ?6 and ?7 inhibit growth and induce apoptosis in human myeloma cells","volume":"23","author":"ro","year":"2004","journal-title":"Oncogene"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.06.003"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.13.1580"},{"key":"ref40","first-page":"37","article-title":"Evaluation: From precision, recall and F-measure to ROC, informedness, markedness and correlation","volume":"2","author":"powers","year":"2011","journal-title":"J Mach Learn Technol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5067-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-355818"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3027-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13116"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2015.1042915"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2017.8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107202"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2018.06.007"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0554-9"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12338"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt344"},{"key":"ref47","first-page":"1160","article-title":"ERK5-regulated RERG expression promotes cancer progression in prostatic carcinoma","volume":"41","author":"xiong","year":"2019","journal-title":"Oncol Rep"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1073-y"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105888200"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/srep29922"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1002\/ijc.25951","article-title":"Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas","volume":"129","author":"\u00f8ster","year":"2011","journal-title":"Int J Cancer"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4031"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027792"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-16"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22107"},{"key":"ref76","first-page":"721","article-title":"Slit3 inhibits activator protein 1-mediated migration of malignant melanoma cells","volume":"28","author":"denk","year":"2011","journal-title":"Int J Mol Med"},{"key":"ref77","first-page":"2883","article-title":"p53AIP1 regulates the mitochondrial apoptotic pathway","volume":"62","author":"matsuda","year":"2002","journal-title":"Cancer Res"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4326-5"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1357"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00073-8"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.08.006"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00527-7"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-28217-3_3"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199906)25:2<191::AID-GCC16>3.0.CO;2-8"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207774"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1177\/117693510700300006"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03612-0"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1053"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28765"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000879"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1068"},{"key":"ref69","first-page":"2904","article-title":"Decreased expression of miR-218 is associated with poor prognosis in patients with colorectal cancer","volume":"6","author":"yu","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012211"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1087"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074334"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.12.022"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40582"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000231"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-171019"},{"key":"ref106","first-page":"1054","article-title":"SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells","volume":"63","author":"dallol","year":"2003","journal-title":"Cancer Res"},{"key":"ref92","first-page":"5595","article-title":"Oncogene miR-934 promotes ovarian cancer cell proliferation and inhibits cell apoptosis through targeting BRMS1L","volume":"23","author":"hu","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21881"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4159"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2084"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0552-9"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2496"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90097-E"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-14-0384-T"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3151"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12986"},{"key":"ref99","first-page":"2426","article-title":"[Maintenance of hematopoietic stem cell integrity and regulation of leukemogenesis by p53 and its coactivator Aspp1]","volume":"56","author":"yamashita","year":"2015","journal-title":"Rinsho Ketsueki"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710756114"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.4161\/onci.21480"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.10.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"970d","DOI":"10.1093\/nar\/gks937","article-title":"TSGene: A Web resource for tumor suppressor genes","volume":"41","author":"zhao","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1268"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2174\/1386207322666181206112641"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000057"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/1574893614666190220114644"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0638"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00680-8"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.470"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2309-9"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2489"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2019.22.e21"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.08.013"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-376"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070772"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13420"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6406"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6287639\/8600701\/08882219.pdf?arnumber=8882219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T19:40:59Z","timestamp":1628624459000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/8882219\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":111,"URL":"https:\/\/doi.org\/10.1109\/access.2019.2949415","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}