{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:25:44Z","timestamp":1792794344830,"version":"4.5.0"},"reference-count":117,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Flanders Research Center, (Fonds Wetenschappelijk Onderzoek\u2013FWO), through the Research Project","doi-asserted-by":"publisher","award":["G026514N"],"award-info":[{"award-number":["G026514N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO-KAN Project","doi-asserted-by":"publisher","award":["1501517N"],"award-info":[{"award-number":["1501517N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015667","name":"a grant from the Romanian National Authority for Scientific Research and Innovation, CNCS\/CCCDI\u2013UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P2-2.1-PED-2019-0322 (PNCDI III)"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-0322 (PNCDI III)"]}],"id":[{"id":"10.13039\/100015667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO Doctoral Grant Fundamental through the Fellowship","doi-asserted-by":"publisher","award":["1184220N"],"award-info":[{"award-number":["1184220N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO Postdoctoral Fellowship","doi-asserted-by":"publisher","award":["12X6819N"],"award-info":[{"award-number":["12X6819N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1109\/access.2020.3037725","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T21:16:33Z","timestamp":1605215793000},"page":"206264-206279","source":"Crossref","is-referenced-by-count":121,"title":["Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives"],"prefix":"10.1109","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-3270","authenticated-orcid":false,"given":"Mihaela","family":"Ghita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Neckebroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-4133","authenticated-orcid":false,"given":"Cristina","family":"Muresan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-830X","authenticated-orcid":false,"given":"Dana","family":"Copot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2927321"},{"key":"ref38","first-page":"2487","article-title":"Estimation of patient sensitivity to drug effect during propofol hypnosis","author":"de keyser","year":"2018","journal-title":"Proc IEEE Int Conf Syst Man Cybern"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.conengprac.2015.09.009"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2016.06.007"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.2968440"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002966"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1109\/SMC.2019.8913957"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.conengprac.2016.08.019"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11071-018-4095-3"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2019.04.003"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1109\/ACC.2016.7526125"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-017-9547-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcon.2015.04.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000769"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00220"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.06.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew312"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.01.018"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2018.06.036"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2017.04.001"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2017.10.003"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.chaos.2017.03.031"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001705"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/ani6110071"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001506"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.18.12720-9"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004388"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-019-00393-x"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2016.08.006"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-020-00511-0"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2854917"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030684"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/asjc.981"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1145\/3140234"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcontrol.2017.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001372"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-013-9535-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1109\/MSMC.2018.2833298"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002634"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004358"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004646"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.03.024"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002663"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.23736\/S0375-9393.16.11602-5","article-title":"Analgesia\/nociception monitoring for opioid guidance: Meta-analysis of randomized clinical trials","volume":"83","author":"gruenewald","year":"2017","journal-title":"Minerva Anestesiologica"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-019-00362-4"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2020.101931"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004208"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815975-0.00007-2"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-016-9868-y"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1097\/CJ9.0000000000000110"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13741-019-0130-2","article-title":"Technical and clinical evaluation of a closed loop TIVA system with SEDLineTM spectral density monitoring: Multicentric prospective cohort study","volume":"9","author":"pe\u00f1aranda","year":"2020","journal-title":"Perioper Med"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.23919\/ECC.2019.8796241"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1109\/TCST.2018.2879290"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu401"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000577"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003014"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1186\/cc10562"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"437","DOI":"10.23736\/S0375-9393.17.11915-2","article-title":"Effects of closed-loop intravenous anesthesia guided by bispectral index in adult patients on emergence delirium: A randomized controlled study","volume":"84","author":"cotoia","year":"2018","journal-title":"Minerva Anestesiologica"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.06.007"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocy131"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004651"},{"key":"ref61","article-title":"SLEEPNET: Automated sleep staging system via deep learning","author":"biswal","year":"2017","journal-title":"arXiv 1707 08262"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7432310"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-019-02683-9"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.23919\/ECC.2019.8795620"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001152"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet001"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-016-9858-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcontrol.2019.03.010"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001737"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/widm.1350"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2016.07.025"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-018-0090-3"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2015.05.013"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2017.12.005"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2018.02.005"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1109\/TFUZZ.2020.2969384"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2019.04.030"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-018-0933-6"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2018.09.015"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2019.01.066"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.18.13058-6"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.3390\/a11070106"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2019.101656"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2019.2898194"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-018-0208-2"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003433"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2014.10.006"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2017.01.033"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1109\/PC.2017.7976251"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1002\/rnc.4374"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2017.02.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-018-1111-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13316"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.03.086"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002657"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2018.06.038"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001636"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-013-9466-1"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2018.12.015"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2015.10.192"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2019.2954348"},{"key":"ref81","first-page":"1","article-title":"Event-based GPC for depth of hypnosis in anesthesia for efficient use of propofol","author":"pawlowski","year":"2017","journal-title":"Proc 3rd Int Conf Event-Based Control Commun Signal Process (EBCCSP)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000051"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.12.016"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001394"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2016.08.019"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.03.013"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318205680b"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-013-9451-8"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2018.01.023"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1109\/TCST.2017.2735359"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2017.08.2238"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1145\/2818302"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000492992.46040.6a"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003470"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2016.04.003"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6287639\/8948470\/09257370.pdf?arnumber=9257370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T22:19:53Z","timestamp":1669587593000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9257370\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":117,"URL":"https:\/\/doi.org\/10.1109\/access.2020.3037725","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}