{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:38:35Z","timestamp":1782920315568,"version":"3.54.5"},"reference-count":152,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"publisher","award":["ECCS-1917166"],"award-info":[{"award-number":["ECCS-1917166"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"publisher","award":["IIP-2136215"],"award-info":[{"award-number":["IIP-2136215"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1109\/access.2023.3283291","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T22:58:52Z","timestamp":1686092332000},"page":"56672-56690","source":"Crossref","is-referenced-by-count":11,"title":["Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean Networks"],"prefix":"10.1109","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9352-1312","authenticated-orcid":false,"given":"Aditya","family":"Lahiri","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-7732","authenticated-orcid":false,"given":"Haswanth","family":"Vundavilli","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-1916","authenticated-orcid":false,"given":"Pranabesh","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Decker","sequence":"additional","affiliation":[{"name":"EMOL Health, Royal Oak, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Del","family":"Priore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-7839","authenticated-orcid":false,"given":"N. Peter","family":"Reeves","sequence":"additional","affiliation":[{"name":"Sumaq Life LLC, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-3807","authenticated-orcid":false,"given":"Aniruddha","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Texas A&#x0026;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12084"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001474"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.7.2015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0431-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60534"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-204154"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1593-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2018.02.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.10.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.3037"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1177"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3859-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23243"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3045"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911432496"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5135"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2016.19.3.223"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202809"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530291100"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1982"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1479"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3301"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12918-018-0655-x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9048-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3033242"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/436792a"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21496"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4137\/CIN.S8283"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/nature11017"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v5.i5.97"},{"issue":"1","key":"ref35","first-page":"113","article-title":"Genetic mutation","volume":"1","author":"Clancy","year":"2008","journal-title":"Nature Educ."},{"key":"ref36","first-page":"218","author":"Ginsburg","year":"2017","journal-title":"Prostate Cancer"},{"key":"ref37","article-title":"mutation","volume-title":"Encyclopedia Britannica","author":"Griffiths"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174269"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.4103\/2395-3977.181437"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0440-y"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.e12564"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1864-1"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45014"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23350"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01616-7"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4129"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.e24216"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.116"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02321-w"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081126"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30898"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.833"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02317-05"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.625"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1085"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-137"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2846"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.692173"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8707053"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416673-8.00013-7"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800785"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020127"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0172"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100127"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.09.005"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.17.5925-5934.2001"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1450406"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4458"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-020-0220-5"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.06.035"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.12.016"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123134119"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.048"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2020.106"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3876"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01397-3"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01020-6"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.5"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.3.015"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.09.009"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.07.007"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5281"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2986"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2635"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3441"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0797-x"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1903"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3684"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.8347"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9290"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.04.013"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000121"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0444.1000351"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01637.x"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.19.9.6195"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1526598"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210546"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169622"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14010411"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58642-y"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22264"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3123"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2628"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.725473"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.786728"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.05.139"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02130-4"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0287-3"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113099"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.694281"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011205"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44745"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1206-z"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.11.010"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4840"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-017-0177-y"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00072"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.12.005"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050465"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12133"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.005"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-0527-z"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx065"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2018.2869813"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-012-0539-4"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-3-88"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.3390\/inventions6020037"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255486"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.4236\/jbise.2013.62A027"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2503"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2021.110647"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejor.2005.11.044"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247190"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-019-1684-3"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(69)90015-0"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1038\/224177a0"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(74)80037-8"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-46"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.03.001"},{"key":"ref141","volume-title":"R: A Language and Environment for Statistical Computing","year":"2021"},{"key":"ref142","volume-title":"National Center for Biotechnology Information","year":"1988"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153854"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071579"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2008.74"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-015-0066-6"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01454-1"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166300"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2017.0020"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.8433"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21600"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3664-1"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"https:\/\/ieeexplore.ieee.org\/ielam\/6287639\/10005208\/10144738-aam.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6287639\/10005208\/10144738.pdf?arnumber=10144738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T16:14:07Z","timestamp":1710346447000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10144738\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":152,"URL":"https:\/\/doi.org\/10.1109\/access.2023.3283291","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.03.539160","asserted-by":"object"}]},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}