{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:22:01Z","timestamp":1771068121566,"version":"3.50.1"},"reference-count":34,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","award":["W81XWH-19-1-0322"],"award-info":[{"award-number":["W81XWH-19-1-0322"]}],"id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1109\/access.2024.3395008","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T17:43:07Z","timestamp":1714412587000},"page":"62511-62525","source":"Crossref","is-referenced-by-count":6,"title":["A Lumped-Parameter Model of the Cardiovascular System Response for Evaluating Automated Fluid Resuscitation Systems"],"prefix":"10.1109","volume":"12","author":[{"given":"Yekanth Ram","family":"Chalumuri","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"}]},{"given":"Ghazal","family":"Arabidarrehdor","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-1109","authenticated-orcid":false,"given":"Ali","family":"Tivay","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-4763","authenticated-orcid":false,"given":"Catherine M.","family":"Sampson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA"}]},{"given":"Muzna","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-546X","authenticated-orcid":false,"given":"Michael","family":"Kinsky","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA"}]},{"given":"George C.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-2836","authenticated-orcid":false,"given":"Jin-Oh","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-0832","authenticated-orcid":false,"given":"Christopher G.","family":"Scully","sequence":"additional","affiliation":[{"name":"Center for Devices and Radiological Health United States Food and Drug Administration, Office of Science and Engineering Laboratories, Silver Spring, MD, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-0851","authenticated-orcid":false,"given":"Ramin","family":"Bighamian","sequence":"additional","affiliation":[{"name":"Center for Devices and Radiological Health United States Food and Drug Administration, Office of Science and Engineering Laboratories, Silver Spring, MD, USA"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000002329"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2810-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1088\/2516-1091\/ac6d36"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.2968440"},{"key":"ref5","volume-title":"Physiological Closed-Loop Controlled Devices; Public Workshop; Request for Comments","year":"2015"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1109\/TII.2012.2226594","article-title":"Model-driven safety analysis of closed-loop medical systems","volume":"10","author":"Pajic","year":"2014","journal-title":"IEEE Trans. Ind. Informat."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814543661"},{"issue":"1","key":"ref8","first-page":"21463","article-title":"Development and validation of a mathematical model of heart rate response to fluid perturbation","volume-title":"Sci. Rep.","volume":"12","author":"Kanal","year":"2022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300106"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3222745"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2020.07.003"},{"issue":"1","key":"ref13","first-page":"12697","article-title":"Mathematical model of blood glucose dynamics by emulating the pathophysiology of glucose metabolism in type 2 diabetes mellitus","volume-title":"Sci. Rep.","volume":"10","author":"L\u00f3pez-Palau","year":"2020"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s002850200135"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2014.2371533"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/459269"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.conengprac.2018.01.008","article-title":"Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation","volume":"73","author":"Bighamian","year":"2018","journal-title":"Control Eng. Pract."},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.642440","article-title":"Closed-loop control for fluid resuscitation: Recent advances and future challenges","volume":"8","author":"Gholami","year":"2021","journal-title":"Frontiers Veterinary Sci."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2880927"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1115\/1.4033833"},{"key":"ref21","volume-title":"Dynamics and Control of the Body Fluids","author":"Guyton","year":"1975"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1733"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00230.2014"},{"key":"ref24","volume-title":"Assessing Credibility of Computational Modeling through Verification and Validation: Application to Medical Devices V V 40","year":"2018"},{"key":"ref25","volume-title":"Assessing the Credibility of Computational Modeling and Simulation in Medical Device Submissions","year":"2023"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00390"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2017.10.006"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1115\/1.3426465"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000135255.59817.8c"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000330"},{"key":"ref31","volume":"1","year":"1993","journal-title":"Guide to the Care and Use of Experimental Animals"},{"key":"ref32","volume-title":"Cardiovascular Physiology Concepts","author":"Klabunde","year":"2011"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-69269-2","volume-title":"Hemodynamic Monitoring","author":"Pinsky","year":"2019"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/CCM.0000000000002593","article-title":"Closed-loop and decision-assist guided fluid therapy of human hemorrhage","volume":"45","author":"Hundeshagen","year":"2017","journal-title":"Crit. Care Med."}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"https:\/\/ieeexplore.ieee.org\/ielam\/6287639\/10380310\/10510286-aam.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6287639\/10380310\/10510286.pdf?arnumber=10510286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:44:12Z","timestamp":1715057052000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10510286\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1109\/access.2024.3395008","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}