{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:15:38Z","timestamp":1767860138743,"version":"3.49.0"},"reference-count":150,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012996","name":"University of Cyprus Scholarship Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1109\/access.2024.3489798","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T17:25:30Z","timestamp":1730481930000},"page":"162359-162391","source":"Crossref","is-referenced-by-count":1,"title":["A Systematic Review of Quantitative MRI Brain Analysis Studies in Multiple Sclerosis Disease"],"prefix":"10.1109","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4863-6505","authenticated-orcid":false,"given":"Andria","family":"Nicolaou","sequence":"first","affiliation":[{"name":"Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-8573","authenticated-orcid":false,"given":"Christos P.","family":"Loizou","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Computer Engineering and Informatics, Cyprus University of Technology, Limassol, Cyprus"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-384X","authenticated-orcid":false,"given":"Marios","family":"Pantzaris","sequence":"additional","affiliation":[{"name":"The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-8151","authenticated-orcid":false,"given":"Constantinos S.","family":"Pattichis","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Biomedical Engineering Research Centre, University of Cyprus, Nicosia, Cyprus"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-5004-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.03.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0412-5"},{"issue":"2","key":"ref4","first-page":"89","article-title":"Immunity and inflammation in neurodegenerative diseases","volume":"2","author":"Cappellano","year":"2013","journal-title":"Am. J. Neurodegener. Dis."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz144"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ins.2011.10.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2012.09.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2018.10.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2020.610967"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11831-020-09403-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10583"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-022-03019-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2022.3151741"},{"key":"ref18","article-title":"A bibliography of multiple sclerosis lesions detection methods using brain MRIs","author":"Shah","year":"2023","journal-title":"arXiv:2302.09516"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103491"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.891486"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0262-8856(03)00137-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00909"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-816176-0.00023-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2018.2890743"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2021.3115703"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/762804"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.1973.4309314"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.1976.5408777"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1109\/21.44046"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1109\/42.141636"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mlwa.2021.100031"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00521-022-07099-3"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/jimaging6060052"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2021.07.016"},{"key":"ref35","article-title":"Explainable AI applications in the medical domain: A systematic review","author":"Prentzas","year":"2023","journal-title":"arXiv:2308.05411"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.011"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12506"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25095"},{"key":"ref40","first-page":"117","article-title":"International Workshop on Machine Learning in Medical Imaging","volume-title":"Proc. Int. Workshop Mach. Learn. Med. Imag.","volume":"8679","author":"Yoo"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.03.002"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-017-9348-7"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2016.03.025"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.aej.2023.04.069"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s11042-023-16292-y"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31207-5"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1167612"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107021"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2022.104965"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1007453"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.964250"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020230"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2021.102312"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1109\/JTEHM.2022.3172025"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-07750-0_31"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-021-02327-y"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.32604\/cmc.2020.012448"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89128-2_25"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79925-4"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1109\/IISEC54230.2021.9672360"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2020.00019"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI45749.2020.9098721"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520921364"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-020-02225-6"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2020.101772"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102445"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102335"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26959"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102149"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.03.068"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519856843"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101638"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75238-9_3"},{"key":"ref74","article-title":"Multiple sclerosis lesion segmentation from brain MRI via fully convolutional neural networks","author":"Roy","year":"2018","journal-title":"arXiv:1803.09172"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.034"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2528821"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101849"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102074"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.011"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.064"},{"key":"ref81","first-page":"126","article-title":"MSSEG-2 challenge proceedings: Multiple sclerosis new lesions segmentation challenge using a data management and processing infrastructure","volume-title":"Proc. 24th Int. Conf. Med. Image Comput. Comput. Assist. Intervent (MICCAI)","author":"Commowick"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118589"},{"key":"ref83","doi-asserted-by":"crossref","DOI":"10.54294\/lmkqvm","article-title":"3D segmentation in the clinic: A grand challenge II at MICCAI 2008: MS lesion segmentation","author":"Styner","year":"2008","journal-title":"Midas J."},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.005"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"ref88","article-title":"Bayesian inference for structured additive regression models for large-scale problems with applications to medical imaging","author":"Schmidt","year":"2016"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01008-z"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.018"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.07.064"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.003"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1109\/42.97590"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1109\/ICIP.2007.4378944"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105363"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2022.109671"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2021.03.016"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06995-3"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.07.007"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2016.2620996"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v7n6p68"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2010.2091279"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9942-9"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101623"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12527"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.suscom.2022.100706"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102412"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.609468"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.101557"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019191061"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.05.009"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI45749.2020.9098554"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1145\/3341095"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51037"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102003"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1166\/jmihi.2019.2692"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00818"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocs.2018.07.003"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2023.3260982"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.31661\/jbpe.v0i0.2302-1597"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-13321-3_32"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.08.022"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2014.05.006"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.3233\/IDT-120147"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.5430\/jbgc.v3n1p20"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119787"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1002\/ima.22492"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00594"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102104"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2008.08.005"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0125"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0339"},{"key":"ref133","article-title":"Very deep convolutional networks for large-scale image recognition","volume-title":"Proc. 3rd Int. Conf. Learn. Represent. (ICLR)","author":"Simonyan"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130140"},{"key":"ref135","first-page":"4844","article-title":"Learning important features through propagating activation differences","volume-title":"Proc. 34th Int. Conf. Mach. Learn. (ICML)","author":"Shrikumar"},{"key":"ref136","article-title":"Deep inside convolutional networks: Visualising image classification models and saliency maps","volume-title":"Proc. 2nd Int. Conf. Learn. Represent. (ICLR)","author":"Simonyan"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1109\/ACPR.2015.7486599"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2017.243"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1145\/3065386"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89128-2_26"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1109\/CBMS.2017.53"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.3233\/AAC-181006"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89128-2_27"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1109\/DSP58604.2023.10167888"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1109\/BHI58575.2023.10313379"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-44240-7_14"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020198"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20054261"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12796"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-68796-0_8"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6287639\/10380310\/10741251.pdf?arnumber=10741251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:48:37Z","timestamp":1732708117000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10741251\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":150,"URL":"https:\/\/doi.org\/10.1109\/access.2024.3489798","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}