{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:16:08Z","timestamp":1783527368196,"version":"3.55.0"},"reference-count":47,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Project: \u201cSTING: Development of a Drug Repositioning Decision Support System for Childhood Acute Leukemia by Digital Twin-Oriented Deep Learning\u201d"},{"name":"Scientific and Technological Research Council of T\u00fcrkiye","award":["123E383"],"award-info":[{"award-number":["123E383"]}]},{"name":"Article Processing Charge (APC) was funded by Suleyman Demirel University, T\u00fcrkiye, under the Suleyman Demirel University Scientist Training and Research and Development Efficiency Increasing Program","award":["FBY-2018-6490"],"award-info":[{"award-number":["FBY-2018-6490"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1109\/access.2025.3599025","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T18:48:28Z","timestamp":1755197308000},"page":"148684-148698","source":"Crossref","is-referenced-by-count":4,"title":["Drug Repositioning for Childhood Acute Lymphoblastic Leukemia Using an Explainable Regularized Bi-LSTM Ensemble and Molecular Docking Validation"],"prefix":"10.1109","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-6415","authenticated-orcid":false,"given":"Utku","family":"Kose","sequence":"first","affiliation":[{"name":"Suleyman Demirel University, Isparta, Türkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-9110","authenticated-orcid":false,"given":"Ilhan","family":"Uysal","sequence":"additional","affiliation":[{"name":"Burdur Mehmet Akif Ersoy University, Burdur, Türkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.53350\/pjmhs2023172445"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215618770"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174290"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-19642-4_31"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5478157"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13089"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3628712"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0325-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/20552076221133703"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010132"},{"key":"ref11","article-title":"Sequence-based drug design using transformers","author":"Vendruscolo","year":"2024","journal-title":"Res. Square Biolog. Sci."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005690"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty593"},{"key":"ref14","article-title":"Atomic convolutional networks for predicting protein-ligand binding affinity","author":"Gomes","year":"2017","journal-title":"arXiv:1703.10603"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00263"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44359"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113568"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c04346"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.61797\/ijbic.v1i2.166"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.628144"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00200"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.25258\/ijpqa.14.2.31"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11924-4"},{"key":"ref25","volume-title":"Protein and ligand dataset for drug repositioning in childhood acute lymphoblastic leukemia (all)","author":"Kose","year":"2025"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29246"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-0931-y"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105049"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1549"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1021\/jm100112j"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1467506"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.26650\/experimed.2021.993743"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/ph16060808"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.12659\/aot.928817"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000002770"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.24875\/ric.24000006"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/mi13050739"},{"key":"ref38","article-title":"Multimodal mapping of human lymphopoiesis reveals B and T\/NK\/ILC lineages are subjected to cell-intrinsic versus Flt3L-dependent regulation","author":"Hussen","year":"2022","journal-title":"bioRxiv.org"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/his.14619"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203113"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20240079"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920963803"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1109\/icict60155.2024.10544998"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg520"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3331"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.011"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6287639\/10820123\/11124916.pdf?arnumber=11124916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:43:29Z","timestamp":1756489409000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11124916\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":47,"URL":"https:\/\/doi.org\/10.1109\/access.2025.3599025","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}