{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:22:19Z","timestamp":1792790539239,"version":"4.5.0"},"reference-count":35,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1109\/access.2026.3727050","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:15:18Z","timestamp":1787598918000},"page":"130343-130366","source":"Crossref","is-referenced-by-count":1,"title":["Hybrid Ensemble Learning and XAI for Cholinesterase Inhibitor Prediction in Alzheimer\u2019s Therapy: An Interpretable Ligand-Based Framework"],"prefix":"10.1109","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5254-8779","authenticated-orcid":false,"given":"Bilal","family":"Ahmad","sequence":"first","affiliation":[{"name":"University of Johannesburg","place":["Johannesburg, South Africa"],"department":["Department of Electrical and Electronic Engineering Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-1265","authenticated-orcid":false,"given":"Alessio","family":"Bechini","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"],"department":["Department of Information Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-5061","authenticated-orcid":false,"given":"Khmaies","family":"Ouahada","sequence":"additional","affiliation":[{"name":"University of Johannesburg","place":["Johannesburg, South Africa"],"department":["Department of Electrical and Electronic Engineering Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7210-8772","authenticated-orcid":false,"given":"Farah","family":"Jabeen","sequence":"additional","affiliation":[{"name":"University of Johannesburg","place":["Johannesburg, South Africa"],"department":["Department of Electrical and Electronic Engineering Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-1012","authenticated-orcid":false,"given":"Habib","family":"Hamam","sequence":"additional","affiliation":[{"name":"University of Johannesburg","place":["Johannesburg, South Africa"],"department":["Department of Electrical and Electronic Engineering Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad445"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180821094047"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1382"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1470"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac956"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1031"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1207"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl999"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp433"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-016-0128-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbu010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00782"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103649"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.134"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2025.12.033"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00552-w"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04650-w"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1176400"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.4c01509"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2021.3103966"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.62411\/jcta.10129"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041681"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-024-00374-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2021.106584"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-022-00296-7"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01101"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70162"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.compeleceng.2022.108475"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10489-021-02454-8"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2025.103301"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6287639\/11323511\/11664384.pdf?arnumber=11664384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:07:36Z","timestamp":1788239256000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11664384\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1109\/access.2026.3727050","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}