{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:14:45Z","timestamp":1792786485271,"version":"4.5.0"},"reference-count":57,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"European Research Council (ERC) Consolidator Grant AMICAS","award":["101043225"],"award-info":[{"award-number":["101043225"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Union","id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Access"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1109\/access.2026.3734062","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:10:18Z","timestamp":1789672218000},"page":"152062-152082","source":"Crossref","is-referenced-by-count":0,"title":["AMICASim: Adaptive Multidrug Control System of Major Surgery Featuring Human-in-the-Loop Capabilities for Balanced Anesthesia Care"],"prefix":"10.1109","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-830X","authenticated-orcid":false,"given":"Dana","family":"Copot","sequence":"first","affiliation":[{"name":"Ghent University","place":["Ghent, Belgium"],"department":["Department of Electromechanics, Systems and Metal Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-6690","authenticated-orcid":false,"given":"Erhan","family":"Yumuk","sequence":"additional","affiliation":[{"name":"Ghent University","place":["Ghent, Belgium"],"department":["Department of Electromechanics, Systems and Metal Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Ayvaz","sequence":"additional","affiliation":[{"name":"Ghent University","place":["Ghent, Belgium"],"department":["Department of Electromechanics, Systems and Metal Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-1009","authenticated-orcid":false,"given":"Robert","family":"Szabo","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy","place":["Cluj-Napoca, Romania"],"department":["Anesthesia and Intensive Care II Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-035X","authenticated-orcid":false,"given":"Clara M.","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Ghent University","place":["Ghent, Belgium"],"department":["Department of Electromechanics, Systems and Metal Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1021\/ie800695b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2008.923142"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2014.07.025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.03.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2022.107747"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2024.3488715"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1109\/LCSYS.2024.3399093"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/s24072031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200403000-00026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1109\/MED.2013.6608720"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2017.08.368"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.conengprac.2018.11.009"},{"key":"ref13","volume-title":"An Overview of TCI & TIVA","author":"Absalom","year":"2019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001892"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.conengprac.2022.105384"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1109\/LCSYS.2024.3411518"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000007289"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2024.11.087"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-026-10026-x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/acs.1073"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3182\/20120829-3-HU-2029.00077"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.23919\/ECC.2019.8795841"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacsc.2020.100121"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2021.12.004"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/app13137381"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2024.08.033"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2025.107506"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1109\/LCSYS.2023.3291665"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2024.103179"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s11071-018-4095-3"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.isatra.2025.01.025"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2016.06.007"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2021.3049880"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/CCTA49430.2022.9966032"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1109\/CDC51059.2022.9992350"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1109\/CCTA49430.2022.9966190"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/fractalfract8110623"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/fractalfract9050317"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2025.108901"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1109\/TIE.2015.2478397"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacsc.2021.100137"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.3007924"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1109\/LCSYS.2024.3402942"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01411-5"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.03.011"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199805000-00006"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199906000-00003"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.1.41"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1097\/00132586-199712000-00024"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1097\/00132586-199712000-00025"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep143"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)06847-4"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacsc.2025.100324"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200604000-00012"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004686"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3673"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000002355"}],"container-title":["IEEE Access"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6287639\/11323511\/11692833.pdf?arnumber=11692833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:12:14Z","timestamp":1791400334000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11692833\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":57,"URL":"https:\/\/doi.org\/10.1109\/access.2026.3734062","relation":{},"ISSN":["2169-3536"],"issn-type":[{"value":"2169-3536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}