{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T21:42:46Z","timestamp":1770846166445,"version":"3.50.1"},"reference-count":22,"publisher":"IEEE","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG069900,R01AG089717,R01AG065611"],"award-info":[{"award-number":["R01AG069900,R01AG089717,R01AG065611"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,15]]},"DOI":"10.1109\/bibm66473.2025.11356826","type":"proceedings-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:19:40Z","timestamp":1769721580000},"page":"1227-1234","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Single Cell RNA Sequencing Data and Protein Embeddings to Infer Cell-Cell Communication in Alzheimer's Disease"],"prefix":"10.1109","author":[{"given":"Yuting","family":"Tan","sequence":"first","affiliation":[{"name":"Vanderbilt University,Department of Molecular Physiology and Biophysics,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Vanderbilt University,Department of Computer Science,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Vanderbilt University,Department of Molecular Physiology and Biophysics,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Vanderbilt University,Department of Molecular Physiology and Biophysics,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhexing","family":"Wen","sequence":"additional","affiliation":[{"name":"Emory University,Department of Psychiatry and Behavioral Sciences,Atlanta,Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhong","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center,Department of Medicine,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Yin","sequence":"additional","affiliation":[{"name":"Vanderbilt University,Department of Computer Science,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingshan","family":"Li","sequence":"additional","affiliation":[{"name":"Vanderbilt University,Department of Molecular Physiology and Biophysics,Nashville,Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51705"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20241276"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-10795-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01888-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0292-x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0667-5"},{"key":"ref8","first-page":"2024","article-title":"Benchmarking text-integrated protein language model embeddings and embedding fusion on diverse downstream tasks","author":"Ko","year":"2024","journal-title":"bioRxiv"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.24963\/ijcai.2021\/214"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07871-6"},{"issue":"5","key":"ref14","first-page":"527","article-title":"Reelin: new roles for an old protein","volume":"19","author":"Herz","year":"2009","journal-title":"Current opinion in neurobiology"},{"issue":"2","key":"ref15","first-page":"128","article-title":"Egf receptor in alzheimer\u2019s disease: signaling mechanisms and therapeutic potential","volume":"36","author":"Zhang","year":"2020","journal-title":"Neuroscience Bulletin"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01774-5"},{"key":"ref18","first-page":"2023","article-title":"Liana+: an all-in-one cell-cell communication framework","author":"Dimitrov","year":"2023","journal-title":"BioRxiv"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117172"},{"issue":"12","key":"ref20","first-page":"937","article-title":"Integrins and cell adhesion molecules in alzheimer\u2019s disease","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regeneration Research"},{"issue":"2","key":"ref21","first-page":"796","article-title":"Thrombospondin-1 triggers integrin-mediated phagocytosis of dead cells in alzheimer\u2019s disease","volume":"26","author":"Caberoy","year":"2012","journal-title":"The FASEB Journal"},{"issue":"11","key":"ref22","first-page":"759","article-title":"Innate immune activation in alzheimer\u2019s disease","volume":"18","author":"Ulrich","year":"2018","journal-title":"Nature Reviews Immunology"}],"event":{"name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","location":"Wuhan, China","start":{"date-parts":[[2025,12,15]]},"end":{"date-parts":[[2025,12,18]]}},"container-title":["2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/11355913\/11355975\/11356826.pdf?arnumber=11356826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:52:46Z","timestamp":1770843166000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11356826\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1109\/bibm66473.2025.11356826","relation":{},"subject":[],"published":{"date-parts":[[2025,12,15]]}}}