{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T01:11:54Z","timestamp":1740100314478,"version":"3.37.3"},"reference-count":70,"publisher":"IEEE","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-009"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-001"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"DOI":"10.1109\/cibcb49929.2021.9562855","type":"proceedings-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T04:00:25Z","timestamp":1634702425000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Discovering Missing Edges in Drug-Protein Networks: Repurposing Drugs for SARS-CoV-2"],"prefix":"10.1109","author":[{"given":"Fatemeh","family":"ZareMehrjardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athar","family":"Omidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Sciortino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan E.R.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Lukeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Alexander","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Othman","family":"Soufan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"year":"2020","author":"kuusisto","journal-title":"Word embedding mining for sars-cov-2 and covid-19 drug repurposing [version 1 peer review 2 approved with reservations]","key":"ref70"},{"key":"ref39","article-title":"Circulating levels of Calcitonin gene-related peptide are lower in COVID-19 patients","volume":"5","author":"ochoa-callejero","year":"2021","journal-title":"Endocrine Society"},{"year":"2020","author":"arya","journal-title":"Potential inhibitors against papain-like protease of novel coronavirus (covid-19) from fda approved drugs","key":"ref38"},{"doi-asserted-by":"publisher","key":"ref33","DOI":"10.2217\/fmb-2020-0074"},{"doi-asserted-by":"publisher","key":"ref32","DOI":"10.3949\/ccjm.87a.ccc046"},{"year":"2020","author":"farag","journal-title":"Identification of fda approved drugs targeting covid-19 virus by structure-based drug repositioning","key":"ref31"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1016\/j.molstruc.2020.129449"},{"key":"ref37","article-title":"Virtual screening and molecular dynamics on blockage of key drug targets as treatment for covid-19 caused by sars-cov-2","author":"huang","year":"2020","journal-title":"Preprints"},{"doi-asserted-by":"publisher","key":"ref36","DOI":"10.1007\/s13337-021-00691-6"},{"doi-asserted-by":"publisher","key":"ref35","DOI":"10.7717\/peerj.9965"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4103\/ijo.IJO_869_20","article-title":"What ophthalmologists should know about conjunctivitis in the covid-19 pandemic?","volume":"68","author":"shetty","year":"2020","journal-title":"Indian Journal of Ophthalmology"},{"doi-asserted-by":"publisher","key":"ref60","DOI":"10.21873\/invivo.12157"},{"doi-asserted-by":"publisher","key":"ref62","DOI":"10.1016\/j.compbiomed.2021.104295"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-020-02928-0","article-title":"Angiotensin ii infusion in covid-19-associated vasodilatory shock: a case series","volume":"24","author":"zangrillo","year":"2020","journal-title":"Crit Care"},{"key":"ref63","first-page":"338","article-title":"Anthraquinones: a promising multi-target therapeutic scaffold to treat covid-19","author":"mazouri","year":"2021","journal-title":"International Journal of Applied Biology and Pharmaceutical Technology"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1016\/j.ejca.2020.04.004"},{"doi-asserted-by":"publisher","key":"ref64","DOI":"10.1080\/07391102.2020.1784291"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1016\/j.critrevonc.2020.102991"},{"key":"ref65","article-title":"Marine red alga porphyridium sp. as a source of sulfated polysaccharides (sps) for combating against covid-19","author":"nagle","year":"2020","journal-title":"Preprints"},{"doi-asserted-by":"publisher","key":"ref66","DOI":"10.1111\/bjh.16873"},{"key":"ref29","article-title":"Multiple myeloma in the time of covid-19","volume":"143","author":"saleh","year":"2020","journal-title":"Acta Haematologica"},{"doi-asserted-by":"publisher","key":"ref67","DOI":"10.1111\/1346-8138.15696"},{"key":"ref68","article-title":"The interactions of nintedanib and oral anticoagulants—molecular mechanisms and clinical implications","volume":"22","author":"grze?k","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"year":"2020","author":"gonzalez-paz","journal-title":"Theoretical molecular docking study of the structural disruption of the viral 3cl-protease of covid19 induced by binding of capsaicin piperine and curcumin part 1 A comparative study with chloroquine and hydrochloroquine two antimalaric drugs","key":"ref69"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/S0140-6736(20)30251-8"},{"year":"2020","journal-title":"World Health Organization","article-title":"Coronavirus disease (covid-19) advice","key":"ref1"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1186\/s13321-016-0177-8"},{"year":"0","author":"landrum","journal-title":"Rdkit in python","key":"ref22"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016\/j.ymeth.2014.08.005"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1021\/acs.jcim.0c00179"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1186\/s13321-016-0128-4"},{"key":"ref26","first-page":"1","article-title":"Identification of doxorubicin as a potential therapeutic against sars-cov-2 (covid-19) protease: a molecular docking and dynamics simulation studies","volume":"0","author":"qazi","year":"2021","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"ref25","first-page":"29","article-title":"Potential treatments for covid-19; a narrative literature review","volume":"8","author":"rismanbaf","year":"2020","journal-title":"Arch Academic Emergency Med"},{"doi-asserted-by":"publisher","key":"ref50","DOI":"10.4236\/jbm.2020.812001"},{"key":"ref51","article-title":"Repurposing of miglustat to inhibit the coronavirus severe acquired respiratory syndrome sars-cov-2","author":"rajasekharan","year":"2020","journal-title":"BioRxiv"},{"doi-asserted-by":"publisher","key":"ref59","DOI":"10.1016\/j.lfs.2020.117627"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"117652","DOI":"10.1016\/j.lfs.2020.117652","article-title":"In silico studies on therapeutic agents for covid-19: Drug repurposing approach","volume":"252","author":"bhumi","year":"2020","journal-title":"Life Sciences"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"138277","DOI":"10.1016\/j.scitotenv.2020.138277","article-title":"Covid-19: A promising cure for the global panic","volume":"725","author":"balachandar","year":"2020","journal-title":"Science of The Total Environment"},{"key":"ref56","article-title":"Effects of ivermectin-azithromycin-cholecalciferol combined therapy on covid-19 infected patients: a proof of concept study","volume":"31","author":"espitia-hernandez","year":"2020","journal-title":"Biomedical Research"},{"key":"ref55","volume":"13","author":"giannini","year":"0","journal-title":"Effectiveness of nn-hospital cholecalciferol use on clinical outcomes in comorbid covid-19 ppatients a hypothesis-generating study"},{"doi-asserted-by":"publisher","key":"ref54","DOI":"10.3389\/fphar.2021.652688"},{"doi-asserted-by":"publisher","key":"ref53","DOI":"10.1001\/jama.2020.22760"},{"key":"ref52","first-page":"1","article-title":"Miglustat: a glycotransferase inhibitor for covid-19 treatment","volume":"15","author":"tatlow","year":"2021","journal-title":"JOURNAL OF HEALTH SCIENCE"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.3390\/ijms20143389"},{"key":"ref11","article-title":"Objective-reinforced generative adversarial networks (organ) for sequence generation models","author":"guimaraes","year":"2017","journal-title":"ArXiv Preprint"},{"doi-asserted-by":"publisher","key":"ref40","DOI":"10.1186\/s13756-020-00820-8"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.3389\/frai.2020.00065"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1186\/s12859-020-03677-1"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1186\/s13321-020-00447-2"},{"key":"ref15","article-title":"A sars-cov-2 protein interaction map reveals targets for drug repurposing","author":"gordon","year":"2020","journal-title":"BioRxiv Prepr Serv Biol"},{"key":"ref16","article-title":"Integration of the drug-gene interaction database (dgidb 4.0) with open crowdsource efforts","author":"freshour","year":"2020","journal-title":"Nucleic Acids Research"},{"year":"2020","author":"bank","journal-title":"Drug bank online dataset","key":"ref17"},{"year":"2020","journal-title":"Chemistry","article-title":"Chembl database","key":"ref18"},{"year":"2020","journal-title":"Pharmacology","article-title":"Pharmgkb data","key":"ref19"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1007\/s00146-020-00978-0"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/j.imu.2020.100413"},{"key":"ref6","first-page":"1025","author":"zheng","year":"2013","journal-title":"Collaborative matrix factorization with multiple similarities for predicting drug-target interactions"},{"key":"ref5","article-title":"Au-todti++: deep unsupervised learning for dti prediction by autoencoders","volume":"22","author":"sajadi","year":"0","journal-title":"BMC Bioinformatics"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1186\/s12859-020-03677-1"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1186\/s12911-020-1052-0"},{"doi-asserted-by":"publisher","key":"ref49","DOI":"10.5935\/0004-2749.20210060"},{"key":"ref9","first-page":"2224","article-title":"Convolutional networks on graphs for learning molecular fingerprints","author":"duvenaud","year":"2015","journal-title":"Advances in neural information processing systems"},{"key":"ref46","article-title":"Clinical evidence for improved outcomes with histamine antagonists and aspirin in 22,560 covid-19 patients","author":"mura","year":"2021","journal-title":"medRxiv"},{"key":"ref45","first-page":"352","article-title":"Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists and sars-cov-2 infection","volume":"3","author":"valera","year":"2020","journal-title":"S Afr Heart J"},{"year":"0","author":"baruchel","journal-title":"Covid-19 and acute lymphoblastic leukemias of children and adolescents First recommendations of the leukemia committee of the french society for the fight against cancers and leukemias in children and adolescents (sfce)","key":"ref48"},{"doi-asserted-by":"publisher","key":"ref47","DOI":"10.1016\/j.jbspin.2020.05.003"},{"doi-asserted-by":"publisher","key":"ref42","DOI":"10.1111\/dth.13616"},{"doi-asserted-by":"publisher","key":"ref41","DOI":"10.1007\/s10067-020-05247-5"},{"doi-asserted-by":"publisher","key":"ref44","DOI":"10.1080\/17460441.2020.1819236"},{"doi-asserted-by":"publisher","key":"ref43","DOI":"10.1111\/bph.15094"}],"event":{"name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","start":{"date-parts":[[2021,10,13]]},"location":"Melbourne, Australia","end":{"date-parts":[[2021,10,15]]}},"container-title":["2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/9562742\/9562772\/09562855.pdf?arnumber=9562855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T15:47:24Z","timestamp":1652197644000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9562855\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":70,"URL":"https:\/\/doi.org\/10.1109\/cibcb49929.2021.9562855","relation":{},"subject":[],"published":{"date-parts":[[2021,10,13]]}}}