{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:08:23Z","timestamp":1771607303102,"version":"3.50.1"},"reference-count":29,"publisher":"IEEE","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-03879"],"award-info":[{"award-number":["RGPIN-2021-03879"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,15]]},"DOI":"10.1109\/cibcb55180.2022.9863052","type":"proceedings-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T19:45:49Z","timestamp":1661543149000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Exploring Multi-Objective Deep Reinforcement Learning Methods for Drug Design"],"prefix":"10.1109","author":[{"given":"Aws Al","family":"Jumaily","sequence":"first","affiliation":[{"name":"Brock University,Department of Computer Science,St. Catharines,Ontario,Canada"}]},{"given":"Muhetaer","family":"Mukaidaisi","sequence":"additional","affiliation":[{"name":"Brock University,Department of Computer Science,St. Catharines,Ontario,Canada"}]},{"given":"Andrew","family":"Vu","sequence":"additional","affiliation":[{"name":"Brock University,Department of Computer Science,St. Catharines,Ontario,Canada"}]},{"given":"Alain","family":"Tchagang","sequence":"additional","affiliation":[{"name":"Digital Technologies Research, Centre National Research Council Canada,Ottawa,Ontario,Canada"}]},{"given":"Yifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Brock University,Department of Computer Science,St. Catharines,Ontario,Canada"}]}],"member":"263","reference":[{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3139\/9783446466081"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.2014.2358639"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2020.103915"},{"key":"ref13","author":"karlsson","year":"1997","journal-title":"Learning to Solve Multiple Goals"},{"key":"ref14","first-page":"135","article-title":"Action selection methods using reinforcement learning","volume":"4","author":"humphrys","year":"1996","journal-title":"From Animals to Animats"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10589-008-9189-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10994-010-5232-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1145\/1390156.1390162"},{"key":"ref18","first-page":"1861","article-title":"Soft actor-critic: Off-policy maximum entropy deep reinforcement learning with a stochastic actor","author":"haarnoja","year":"2018","journal-title":"International Conference on Machine Learning"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00501-7"},{"key":"ref28","article-title":"Sample efficient actor-critic with experience replay","author":"wang","year":"2016","journal-title":"ArXiv Preprint"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47148-x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.9997"},{"key":"ref3","article-title":"Hit and lead discovery with explorative RL and fragment-based molecule generation","volume":"34","author":"yang","year":"2021","journal-title":"Advances in neural information processing systems"},{"key":"ref6","first-page":"8366","article-title":"Reinforced molecular optimization with neighborhood-controlled grammars","volume":"33","author":"xu","year":"2020","journal-title":"Advances in neural information processing systems"},{"key":"ref29","article-title":"Prox-imal policy optimization algorithms","author":"schulman","year":"2017","journal-title":"ArXiv Preprint"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aap7885"},{"key":"ref8","author":"sutton","year":"2018","journal-title":"Reinforcement Learning An Introduction"},{"key":"ref7","author":"graesser","year":"2019","journal-title":"Foundations of deep reinforcement learning Theory and practice in Python"},{"key":"ref2","author":"brown","year":"2015","journal-title":"silico Medicinal Chemistry Computational Methods to Support Drug Design"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1609\/aaai.v35i1.16087","article-title":"Towered actor critic for handling multiple action types in reinforcement learning for drug discovery","volume":"35","author":"gottipati","year":"2021","journal-title":"Proceedings of the AAAI Conference on Artificial Intelligence"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00325"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-1-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319010027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM47256.2019.8982964"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1074d","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A major update to the DrugBank database for 2018","volume":"46","author":"wishart","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv082"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-statistics-030718-104938"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1031"}],"event":{"name":"2022 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","location":"Ottawa, ON, Canada","start":{"date-parts":[[2022,8,15]]},"end":{"date-parts":[[2022,8,17]]}},"container-title":["2022 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/9862939\/9863009\/09863052.pdf?arnumber=9863052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T03:21:01Z","timestamp":1676517661000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9863052\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1109\/cibcb55180.2022.9863052","relation":{},"subject":[],"published":{"date-parts":[[2022,8,15]]}}}