{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:16:58Z","timestamp":1769638618364,"version":"3.49.0"},"reference-count":32,"publisher":"IEEE","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018696","name":"Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"DOI":"10.1109\/embc46164.2021.9630862","type":"proceedings-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:24:16Z","timestamp":1639085056000},"page":"4230-4233","source":"Crossref","is-referenced-by-count":6,"title":["A Multiscale Model to Identify Limiting Factors in Nanoparticle-Based miRNA Delivery for Tumor Inhibition"],"prefix":"10.1109","author":[{"given":"Prashant","family":"Dogra","sequence":"first","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier Ruiz","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Butner","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Pelaez","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Cristini","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute,Mathematics in Medicine Program,Houston,TX,USA,77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.84.2064"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s12575-009-9008-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.16.5"},{"key":"ref12","first-page":"3449","volume":"48","author":"kim","year":"1988","journal-title":"Cancer Research"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.02.014"},{"key":"ref14","first-page":"2641","volume":"48","author":"jain","year":"1988","journal-title":"Cancer Research"},{"key":"ref15","first-page":"4285","volume":"57","author":"o'connor","year":"1997","journal-title":"Cancer Research"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65006-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690416"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-355X(99)80001-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00117"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp416"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4498"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00035"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.10.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4324\/9781315374499"},{"key":"ref29","article-title":"Quest Calculate™ RNA Molecular Weight Calculator","author":"bioquest","year":"2021"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004969"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25878-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1628"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03552"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06730-z"},{"key":"ref1","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","volume":"99","author":"calin","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1101\/gr.198788.115"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.09.081"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-019-0380-2"},{"key":"ref24","author":"gorur","year":"2021","journal-title":"Molecular Therapy - Nucleic Acids"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-951"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1049\/iet-syb.2013.0026"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00183"}],"event":{"name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","location":"Mexico","start":{"date-parts":[[2021,11,1]]},"end":{"date-parts":[[2021,11,5]]}},"container-title":["2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/9629355\/9629471\/09630862.pdf?arnumber=9630862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T19:13:27Z","timestamp":1674155607000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9630862\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":32,"URL":"https:\/\/doi.org\/10.1109\/embc46164.2021.9630862","relation":{},"subject":[],"published":{"date-parts":[[2021,11,1]]}}}