{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:12:00Z","timestamp":1774419120670,"version":"3.50.1"},"reference-count":25,"publisher":"IEEE","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,6]]},"DOI":"10.1109\/icassp49660.2025.10888039","type":"proceedings-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T17:15:02Z","timestamp":1741799702000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["NanoGen: A High-affinity Nanobody Generation Model with Guided Diffusion"],"prefix":"10.1109","author":[{"given":"Dezhi","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University,Computer Science and Engineering,Shanghai,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Fudan University,Institutes of Biomedical Sciences,Shanghai,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Qin","sequence":"additional","affiliation":[{"name":"Tsinghua University,School of Clinical Medicine,Beijing,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Linker","sequence":"additional","affiliation":[{"name":"Merck KGaA,Digital Chemistry,Darmstadt,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Hrovatin","sequence":"additional","affiliation":[{"name":"Merck KGaA,Digital Chemistry,Darmstadt,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Hopp","sequence":"additional","affiliation":[{"name":"Merck KGaA,AI & Quantum Lab,Darmstadt,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Tan","sequence":"additional","affiliation":[{"name":"Merck KGaA,AI & Quantum Lab,Darmstadt,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065994"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR00306F"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020238"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgae184"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S399322"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1021\/cr960065d"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.03.009"},{"key":"ref9","article-title":"Denoising diffusion implicit models","author":"Song","year":"2020"},{"key":"ref10","first-page":"6840","article-title":"Denoising diffusion probabilistic models","volume":"33","author":"Ho","year":"2020","journal-title":"Advances in neural information processing systems"},{"key":"ref11","first-page":"22 863","article-title":"A variational perspective on diffusion-based generative models and score matching","volume":"34","author":"Huang","year":"2021","journal-title":"Advances in Neural Information Processing Systems"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbae033"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.channels.700"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe3255"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18174-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-021-00750-5"},{"key":"ref17","article-title":"Antipasti: interpretable prediction of antibody binding affinity exploiting normal modes and deep learning","author":"Kevin Michalewicz","year":"2023","journal-title":"bioRxiv"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02201-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1043"},{"key":"ref20","article-title":"Protein design with guided discrete diffusion","volume":"36","author":"Gruver","year":"2024","journal-title":"Advances in neural information processing systems"},{"key":"ref21","first-page":"17 981","article-title":"Structured denoising diffusion models in discrete state-spaces","volume":"34","author":"Austin","year":"2021","journal-title":"Advances in Neural Information Processing Systems"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2024.01.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1021"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800708"},{"key":"ref25","article-title":"CD45 Binding Molecules and Methods of Use","volume-title":"Patent","author":"Lupardus","year":"2022"}],"event":{"name":"ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)","location":"Hyderabad, India","start":{"date-parts":[[2025,4,6]]},"end":{"date-parts":[[2025,4,11]]}},"container-title":["ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10887540\/10887541\/10888039.pdf?arnumber=10888039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:20:36Z","timestamp":1774416036000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10888039\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,6]]},"references-count":25,"URL":"https:\/\/doi.org\/10.1109\/icassp49660.2025.10888039","relation":{},"subject":[],"published":{"date-parts":[[2025,4,6]]}}}