{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:48:20Z","timestamp":1783183700346,"version":"3.54.6"},"reference-count":55,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"}],"funder":[{"name":"J.-A. DeS\u00e8ve Research Chair"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1109\/jbhi.2016.2593630","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T18:18:23Z","timestamp":1469038703000},"page":"1163-1171","source":"Crossref","is-referenced-by-count":16,"title":["Modeling Glucagon Action in Patients With Type 1 Diabetes"],"prefix":"10.1109","volume":"21","author":[{"given":"A.","family":"Emami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph El","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Rabasa-Lhoret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Castle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Haidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref39","article-title":"The effect of physiologic changes in insulin on gluconeogenesis in the conscious dog","volume":"48","author":"edgerton","year":"1999","journal-title":"Diabetes"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.292"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90192-F"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108649"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108523"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00236.2015"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00581.2011"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2012.01.010"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0803"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90204-8"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700416"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300514"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2008.4650446"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0165"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.04.001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2013.2272736"},{"key":"ref22","first-page":"98a","article-title":"Model predictive method and system for controlling and supervising insulin infusion","volume":"55","author":"kanderian","year":"2006","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300106"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.38.12.1512"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-005-0012-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00304.2001"},{"key":"ref25","first-page":"1024e","article-title":"The hot IVGTT two-compartment minimal model: Indexes of glucose effectiveness and insulin sensitivity","volume":"273","author":"vicini","year":"1997","journal-title":"Amer J Physiol"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00353"},{"key":"ref51","first-page":"735","article-title":"The method of weighted residuals&#x2014;A review","volume":"19","author":"finlayson","year":"1966","journal-title":"Appl Mech Rev"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90051-9"},{"key":"ref54","first-page":"133","volume":"66 2","author":"samols","year":"1983","journal-title":"Intraislet Insulin&#x2014;Glucagon&#x2013;Somatostatin Relationships"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1109\/ACC.2015.7172134"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9574.00060"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.32"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509351"},{"key":"ref40","author":"cherrington","year":"2001","journal-title":"Control of Glucose Production in Vivo by Insulin and Glucagon"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121265"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2254"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000619"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0654"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.130011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2015.2470521"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1932296813514502","article-title":"The UVA\/PADOVA type 1 diabetes simulator: New features","volume":"8","author":"man","year":"2014","journal-title":"J Diabetes Sci Technol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400117"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"ref6","first-page":"117","article-title":"Findings from the Hvidore Study Group on childhood diabetes: Metabolic control and quality of life","volume":"57","author":"mortensen","year":"2002","journal-title":"Horm Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1715"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1056\/NEJMra1215228","article-title":"Mechanisms of hypoglycemia-associated autonomic failure in diabetes","volume":"369","author":"longo","year":"2013","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1084"},{"key":"ref49","article-title":"WinBUGS Differential Interface&#x2014;Worked examples","author":"lunn","year":"2004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1231"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(78)90213-5"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.26.3.177"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1023\/A:1008929526011","article-title":"WinBUGS&#x2014;A Bayesian modelling framework: Concepts, structure, and extensibility","volume":"10","author":"lunn","year":"2000","journal-title":"Stat Comput"},{"key":"ref47","article-title":"Introducing markov chain monte carlo.","author":"gilks","year":"1996","journal-title":"Markov Chain Monte Carlo in Practice"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2337\/diab.23.9.725"},{"key":"ref41","first-page":"263e","article-title":"Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency","volume":"236","author":"cherrington","year":"1979","journal-title":"Amer J Physiol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-50-4-698"},{"key":"ref43","first-page":"194e","article-title":"Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs","volume":"268","author":"wada","year":"1995","journal-title":"Amer J Physiol"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6221020\/7963898\/07517341.pdf?arnumber=7517341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T16:40:27Z","timestamp":1642005627000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/7517341\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":55,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2016.2593630","relation":{},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}